PUMA - pooled uranium miners analysis: cohort profile.
Cigarette Smoking
/ epidemiology
Cohort Studies
Europe
/ epidemiology
Female
Humans
Lung Neoplasms
/ epidemiology
Male
Miners
Neoplasms, Radiation-Induced
/ epidemiology
North America
/ epidemiology
Occupational Diseases
/ epidemiology
Occupational Exposure
/ adverse effects
Radon
/ adverse effects
Risk Assessment
Uranium
Radon
cancer
cardiovascular
low-level ionising radiation
uranium miners
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
28
05
2019
revised:
02
12
2019
accepted:
21
12
2019
pubmed:
2
2
2020
medline:
24
6
2020
entrez:
2
2
2020
Statut:
ppublish
Résumé
Epidemiological studies of underground miners have provided clear evidence that inhalation of radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. The Pooled Uranium Miner Analysis (PUMA) assembles information on cohorts of uranium miners in North America and Europe. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker and information on vital status, date of death and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure and non-radiological occupational exposures. The PUMA study represents the largest study of uranium miners conducted to date, encompassing 124 507 miners, 4.51 million person-years at risk and 54 462 deaths, including 7825 deaths due to lung cancer. Planned research topics include analyses of associations between radon exposure and mortality due to lung cancer, cancers other than lung, non-malignant disease, modifiers of these associations and characterisation of overall relative mortality excesses and lifetime risks. PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.
Identifiants
pubmed: 32005674
pii: oemed-2019-105981
doi: 10.1136/oemed-2019-105981
pmc: PMC8663280
mid: NIHMS1754446
doi:
Substances chimiques
Uranium
4OC371KSTK
Radon
Q74S4N8N1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
194-200Subventions
Organisme : NIOSH CDC HHS
ID : R03 OH010946
Pays : United States
Organisme : NIOSH CDC HHS
ID : R21 OH011452
Pays : United States
Organisme : ACL HHS
ID : R21OH011452
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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