Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling.
Animals
Astrocytes
/ cytology
Bone Morphogenetic Protein Receptors, Type I
/ genetics
Bone Morphogenetic Proteins
/ metabolism
Fibrinogen
/ metabolism
Gene Expression Regulation
Hippocampus
/ cytology
Lateral Ventricles
/ cytology
Mice
Mice, Inbred C57BL
Neural Stem Cells
/ cytology
Neurogenesis
Signal Transduction
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 01 2020
31 01 2020
Historique:
received:
13
08
2018
accepted:
09
01
2020
entrez:
2
2
2020
pubmed:
2
2
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to brain repair during CNS disease. The microenvironment within the SVZ stem cell niche controls NSPC fate. However, extracellular factors within the niche that trigger astrogliogenesis over neurogenesis during CNS disease are unclear. Here, we show that blood-derived fibrinogen is enriched in the SVZ niche following distant cortical brain injury in mice. Fibrinogen inhibited neuronal differentiation in SVZ and hippocampal NSPCs while promoting astrogenesis via activation of the BMP receptor signaling pathway. Genetic and pharmacologic depletion of fibrinogen reduced astrocyte formation within the SVZ after cortical injury, reducing the contribution of SVZ-derived reactive astrocytes to lesion scar formation. We propose that fibrinogen is a regulator of NSPC-derived astrogenesis from the SVZ niche via BMP receptor signaling pathway following injury.
Identifiants
pubmed: 32005867
doi: 10.1038/s41467-020-14466-y
pii: 10.1038/s41467-020-14466-y
pmc: PMC6994610
doi:
Substances chimiques
Bone Morphogenetic Proteins
0
Fibrinogen
9001-32-5
Bone Morphogenetic Protein Receptors, Type I
EC 2.7.11.30
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
630Subventions
Organisme : NINDS NIH HHS
ID : R35 NS097976
Pays : United States
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