The role of absolute monocyte counts in predicting severity of necrotizing enterocolitis.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
08
2019
accepted:
15
01
2020
revised:
09
12
2019
pubmed:
2
2
2020
medline:
1
9
2021
entrez:
2
2
2020
Statut:
ppublish
Résumé
Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm infants marked by an absolute monocyte count (AMC) drop in peripheral blood. Our objective was to determine whether the degree of AMC drop at illness onset correlates with eventual severity of disease. The percentage change in AMC was retrospectively calculated for each of 29 rule-out NEC and 76 NEC cases from baseline to illness onset, and then compared across stages. Median AMC changes of +0.5% (p = 0.56) were found in rule-out NEC, compared with -44.5% (p < 0.0001) in Stage 2 and -81.9% (p < 0.0001) in Stage 3. An AMC change cutoff of -75% distinguishes Stages 2 and 3. The severity of NEC correlated with the extent of AMC change in a dose-response fashion. Percent AMC change may be a useful marker for identifying NEC at onset and prognosticating disease severity.
Identifiants
pubmed: 32005918
doi: 10.1038/s41372-020-0596-2
pii: 10.1038/s41372-020-0596-2
pmc: PMC7985952
mid: NIHMS1677715
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
922-927Subventions
Organisme : NICHD NIH HHS
ID : T32 HD044355
Pays : United States
Références
Patel RM, Kandefer S, Walsh MC, Bell EF, Carlo WA, Laptook AR, et al. Causes and timing of death in extremely premature infants from 2000 through 2011. N. Engl J Med. 2015;372:331–40.
doi: 10.1056/NEJMoa1403489
Niño DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nat Rev Gastroenterol Hepatol. 2016;13:590–600.
doi: 10.1038/nrgastro.2016.119
Hackam D, Caplan M. Necrotizing enterocolitis: pathophysiology from a historical context. Semin Pediatr Surg. 2018;27:11–8.
doi: 10.1053/j.sempedsurg.2017.11.003
Mara MA, Good M, Weitkamp J-H. Innate and adaptive immunity in necrotizing enterocolitis. Semin Fetal Neonatal Med. 2018;23:394–9.
doi: 10.1016/j.siny.2018.08.002
Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011;364:255–64
doi: 10.1056/NEJMra1005408
Remon J, Kampanatkosol R, Kaul RR, Muraskas JK, Christensen RD, Maheshwari A. Acute drop in blood monocyte count differentiates NEC from other causes of feeding intolerance. J Perinatol. 2014;34:549–54.
doi: 10.1038/jp.2014.52
Condino AA, Barleycorn AA, Lu W, Maheshwari A, Christensen RD, Calhoun DA. Abnormal intestinal histology in neonates with congenital anomalies of the gastrointestinal tract. Neonatology. 2004;85:145–50.
doi: 10.1159/000075064
MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, et al. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions. Nat Commun. 2019;10. http://www.nature.com/articles/s41467-019-11199-5 . Accessed 26 Aug 2019.
Lupton BA, Pendray MR. Regionalized neonatal emergency transport. Semin Neonatol. 2004;9:125–33.
doi: 10.1016/j.siny.2003.08.007
Cantey JB, Milstone AM. Bloodstream Infections. Clin Perinatol. 2015;42:1–16.
doi: 10.1016/j.clp.2014.10.002
Lam HS, Ng PC. Use of prokinetics in the preterm infant. Curr Opin Pediatr. 2011;23:156–60.
doi: 10.1097/MOP.0b013e3283431f2a
de Jong E, Strunk T, Burgner D, Lavoie PM, Currie A. The phenotype and function of preterm infant monocytes: implications for susceptibility to infection. J Leukoc Biol. 2017;102:645–56.
doi: 10.1189/jlb.4RU0317-111R
Kalhan TG, Bateman DA, Bowker RM, Hod EA, Kashyap S. Effect of red blood cell storage time on markers of hemolysis and inflammation in transfused very low birth weight infants. Pediatr Res. 2017;82:964–9.
doi: 10.1038/pr.2017.177
Ellefson AM, Locke RG, Zhao Y, Mackley AB, Paul DA. Increased monocytes and bands following a red blood cell transfusion. J Perinatol. 2016;36:57–60.
doi: 10.1038/jp.2015.153