Gastroprotective properties of Lupeol-derived ester: Pre-clinical evidences of Lupeol-stearate as a potent antiulcer agent.
Animals
Anti-Ulcer Agents
/ administration & dosage
Disease Models, Animal
Esterification
Ethanol
/ toxicity
Gastric Mucosa
/ drug effects
Hydrochloric Acid
/ toxicity
Indomethacin
/ toxicity
Mice
NG-Nitroarginine Methyl Ester
/ metabolism
Nitric Oxide
/ metabolism
Pentacyclic Triterpenes
/ administration & dosage
Rats
Rats, Wistar
Stomach Ulcer
/ chemically induced
Structure-Activity Relationship
Esterification
Gastric healing
Oxidative stress
Semisynthetic compounds
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
received:
09
07
2019
revised:
17
01
2020
accepted:
24
01
2020
pubmed:
2
2
2020
medline:
31
3
2020
entrez:
2
2
2020
Statut:
ppublish
Résumé
Lupeol (1) was isolated from hexane branch extract of Maytenus salicifolia and the Lupeol stearate (2), Lupeol palmitate (3), Lupeol myristate (4), Lupeol laurate (5) and Lupeol caprylate (6) were obtained reacting 1 with an adequate carboxylic acid. Swiss mice were treated with vehicle, carbenoxolone or Lupeol esters before administration of ethanol/HCl or indomethacin. Additionally, the involvement of nitric oxide (NO), sulfhydryl compounds (NP-SH), α-2 adrenergic receptors (α2-AR) and prostaglandins (PGE) in antiulcer effects was investigated using appropriate inhibitors or antagonist. Oxidative and inflammatory parameters were measured after euthanasia and anti-secretory effects was evaluated in pylorus-ligated rats. Ethanol/HCl ulcerated the gastric mucosa by 64.45 ± 6.58 mm
Identifiants
pubmed: 32006539
pii: S0009-2797(19)31180-9
doi: 10.1016/j.cbi.2020.108964
pii:
doi:
Substances chimiques
Anti-Ulcer Agents
0
Pentacyclic Triterpenes
0
Nitric Oxide
31C4KY9ESH
Ethanol
3K9958V90M
lupeol
O268W13H3O
Hydrochloric Acid
QTT17582CB
NG-Nitroarginine Methyl Ester
V55S2QJN2X
Indomethacin
XXE1CET956
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108964Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.