Increased global cognition correlates with increased thalamo-temporal connectivity in response to targeted cognitive training for recent onset schizophrenia.
Cognition
Cognitive training
Connectivity
Schizophrenia
Thalamus
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
12
11
2019
revised:
10
01
2020
accepted:
19
01
2020
pubmed:
3
2
2020
medline:
22
6
2021
entrez:
3
2
2020
Statut:
ppublish
Résumé
Patients with schizophrenia exhibit disrupted thalamocortical connections that relate to aspects of symptoms and deficits in cognition. Targeted cognitive training (TCT) of the auditory system in schizophrenia has been shown to improve cognition, but its impact on thalamocortical connectivity is not known. Here we examined thalamocortical connections that may be neuroplastic in response to TCT using a region of interest (ROI) approach. Participants were randomly assigned to either 40 h of TCT (N = 24) or an active control condition (CG; N = 20). Participants underwent resting state fMRI and cognitive testing both before and after training. Changes in thalamocortical connectivity were measured in 15 ROIs derived from a previous study comparing a large sample of schizophrenia subjects with healthy controls. A significant group by time interaction was observed in a left superior temporal ROI which was previously found to exhibit thalamocortical hyper-connectivity in patients with schizophrenia. Changes in this ROI reflected thalamic connectivity increases in the TCT group, while the CG group showed decreases. Additionally, the relationship between connectivity change and change in global cognition showed a slope difference between groups, with increases in thalamo-temporal connectivity correlating with improvements in global cognition in TCT. No significant relationships were observed with changes in clinical symptoms or functioning. These findings demonstrate that TCT may influence intrinsic functional connections in young individuals with schizophrenia, such that improvements in cognition correspond to compensatory increases in connectivity in a temporal region previously shown to exhibit thalamic hyper-connectivity.
Identifiants
pubmed: 32007346
pii: S0920-9964(20)30036-0
doi: 10.1016/j.schres.2020.01.020
pmc: PMC7299776
mid: NIHMS1553936
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-137Subventions
Organisme : NIMH NIH HHS
ID : K01 MH117451
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076989
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH076989
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest SV has served as a paid consultant to Posit Science Inc. In the past three years, DHM has received compensation as a consultant for Boehringer-Ingelheim, Amgen, and Hoffmann-LaRoche. The other authors declare no conflict of interest.
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