Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis.
Borrelia
immunotolerance
saliva
skin immunity
tick
vector-borne diseases
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
01
09
2019
revised:
27
11
2019
accepted:
25
12
2019
pubmed:
3
2
2020
medline:
1
12
2020
entrez:
3
2
2020
Statut:
ppublish
Résumé
The skin plays a key role in vector-borne diseases because it is the site where the arthropod coinoculates pathogens and its saliva. Lyme borreliosis, particularly well investigated in this context, is a multisystemic infectious disease caused by Borrelia burgdorferi sensu lato and transmitted by the hard tick Ixodes. Numerous in vitro studies were conducted to better understand the role of specific skin cells and tick saliva in host defense, vector feeding, and pathogen transmission. The skin was also evidenced in various animal models as the site of bacterial multiplication and persistence. We present the achievements in this field as well as the gaps that impede comprehensive knowledge of the disease pathophysiology and the development of efficient diagnostic tools and vaccines in humans.
Identifiants
pubmed: 32007396
pii: S1471-4922(20)30010-6
doi: 10.1016/j.pt.2019.12.017
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
304-314Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.