Adult hippocampal neurogenesis and antidepressants effects.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
06
11
2019
accepted:
21
11
2019
pubmed:
3
2
2020
medline:
1
6
2021
entrez:
3
2
2020
Statut:
ppublish
Résumé
The hippocampus is particularly involved in cognitive processes and is a key regulator of stress responses and emotions. Therefore, the role of adult-born neurons in this region has become a crucial field of research in order to understand mood and stress disorders, such as major depression. Many studies have characterized the role of these neurons in cognition, mood regulation and antidepressant actions. Nevertheless, the precise mechanisms underpinning these antidepressant effects remain unclear. In this review, we first discuss the effects of stress and antidepressant treatments on adult-born neurons, and subsequently, the role and mechanisms of neurogenesis in antidepressant action. Some studies have shown that adult-born neurons could affect overall hippocampal activity, thus normalizing the latter which could restore neuronal pathways underlying antidepressant effects.
Identifiants
pubmed: 32007727
pii: S1471-4892(19)30122-5
doi: 10.1016/j.coph.2019.11.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-95Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.