Sleep-disordered breathing in adolescents with obesity: When does it start to affect cardiometabolic health?
Adiposity
Adolescent
Age Factors
Biomarkers
/ blood
Blood Glucose
/ metabolism
Blood Pressure
Brazil
Energy Metabolism
Female
France
Humans
Insulin Resistance
Lipids
/ blood
Lung
/ physiopathology
Male
Metabolic Syndrome
/ blood
Pediatric Obesity
/ blood
Respiration
Risk Assessment
Risk Factors
Sleep
Sleep Apnea Syndromes
/ blood
Cardiometabolic risk
MetScore
Metabolic syndrome
Pediatric obesity
Polysomnography
Sleep apnea
Sleep-disordered breathing
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
12 04 2020
12 04 2020
Historique:
received:
29
07
2019
revised:
29
10
2019
accepted:
03
12
2019
pubmed:
6
2
2020
medline:
15
9
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
Pediatric obesity and sleep-disordered breathing (SDB) are associated with cardiometabolic risk (CMR), but the degree of severity at which SDB affects cardiometabolic health is unknown. We assessed the relationship between the CMR and the apnea-hypopnea index (AHI), to identify a threshold of AHI from which an increase in the CMR is observed, in adolescents with obesity. We also compared the clinical, cardiometabolic and sleep characteristics between adolescents presenting a high (CMR+) and low CMR (CMR-), according to the threshold of AHI. 114 adolescents with obesity were recruited from three institutions specialized in obesity management. Sleep and SDB as assessed by polysomnography, anthropometric parameters, fat mass (FM), glucose and lipid profiles, and blood pressure (BP) were measured at admission. Continuous (MetScore The identification of a threshold of AHI ≥ 2 corresponding to the cardiometabolic alterations highlights the need for the early management of SDB and obesity in adolescents, to prevent cardiometabolic diseases. NCT03466359, NCT02588469 and NCT01358773.
Sections du résumé
BACKGROUND AND AIMS
Pediatric obesity and sleep-disordered breathing (SDB) are associated with cardiometabolic risk (CMR), but the degree of severity at which SDB affects cardiometabolic health is unknown. We assessed the relationship between the CMR and the apnea-hypopnea index (AHI), to identify a threshold of AHI from which an increase in the CMR is observed, in adolescents with obesity. We also compared the clinical, cardiometabolic and sleep characteristics between adolescents presenting a high (CMR+) and low CMR (CMR-), according to the threshold of AHI.
METHODS AND RESULTS
114 adolescents with obesity were recruited from three institutions specialized in obesity management. Sleep and SDB as assessed by polysomnography, anthropometric parameters, fat mass (FM), glucose and lipid profiles, and blood pressure (BP) were measured at admission. Continuous (MetScore
CONCLUSIONS
The identification of a threshold of AHI ≥ 2 corresponding to the cardiometabolic alterations highlights the need for the early management of SDB and obesity in adolescents, to prevent cardiometabolic diseases.
CLINICAL TRIALS
NCT03466359, NCT02588469 and NCT01358773.
Identifiants
pubmed: 32008915
pii: S0939-4753(19)30450-8
doi: 10.1016/j.numecd.2019.12.003
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Lipids
0
Banques de données
ClinicalTrials.gov
['NCT03466359', 'NCT02588469', 'NCT01358773']
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-693Informations de copyright
Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.