Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model.
Animals
Anti-Bacterial Agents
/ chemistry
Catheter-Related Infections
/ prevention & control
Catheters
Coated Materials, Biocompatible
/ chemistry
Nitric Oxide
/ chemistry
Rabbits
Staphylococcal Infections
/ prevention & control
Staphylococcus aureus
/ growth & development
Thrombosis
/ prevention & control
CLABSI
antifouling
antimicrobial
catheter
in vivo
nitric oxide
zwitterion
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
pubmed:
6
2
2020
medline:
20
11
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
The development of nonfouling and antimicrobial materials has shown great promise for reducing thrombosis and infection associated with medical devices with aims of improving device safety and decreasing the frequency of antibiotic administration. Here, the design of an antimicrobial, anti-inflammatory, and antithrombotic vascular catheter is assessed in vivo over 7 d in a rabbit model. Antimicrobial and antithrombotic activity is achieved through the integration of a nitric oxide donor, while the nonfouling surface is achieved using a covalently bound phosphorylcholine-based polyzwitterionic copolymer topcoat. The effect of sterilization on the nonfouling nature and nitric oxide release is presented. The catheters reduced viability of
Identifiants
pubmed: 32009376
doi: 10.1021/acsami.9b22442
pmc: PMC7946114
mid: NIHMS1677372
doi:
Substances chimiques
Anti-Bacterial Agents
0
Coated Materials, Biocompatible
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9070-9079Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL134899
Pays : United States
Commentaires et corrections
Type : ErratumIn
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