Piperine fast disintegrating tablets comprising sustained-release matrix pellets with enhanced bioavailability: formulation,
Administration, Oral
Alkaloids
/ administration & dosage
Animals
Benzodioxoles
/ administration & dosage
Biological Availability
Delayed-Action Preparations
Dogs
Drug Compounding
/ methods
Drug Liberation
Drug Stability
Excipients
/ chemistry
Male
Piperidines
/ administration & dosage
Polyunsaturated Alkamides
/ administration & dosage
Solubility
Surface Properties
Tablets
Piperine
bioavailability
fast disintegrating tablets
matrix pellets
solid dispersion
Journal
Pharmaceutical development and technology
ISSN: 1097-9867
Titre abrégé: Pharm Dev Technol
Pays: England
ID NLM: 9610932
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
6
2
2020
medline:
15
1
2021
entrez:
4
2
2020
Statut:
ppublish
Résumé
Piperine (Pip) has been widely studied for its multiple activities such as antidepressant, anti-epileptic, and so forth. However, the poor water solubility coupled with low bioavailability may inevitably hinder the application of Pip in the clinical setting. In this study, a formulation strategy was proposed to spontaneously resolve the low bioavailability and dose dividing issue of Pip. The matrix pellets (Pip-SR-pellets) consisting of Pip solid dispersion (Pip-SD) and hydroxypropylmethyl cellulose-K100 were developed to achieve an increased and sustained release profile
Identifiants
pubmed: 32009511
doi: 10.1080/10837450.2020.1725892
doi:
Substances chimiques
Alkaloids
0
Benzodioxoles
0
Delayed-Action Preparations
0
Excipients
0
Piperidines
0
Polyunsaturated Alkamides
0
Tablets
0
piperine
U71XL721QK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM