Effect of Combination of Ketamine and Propofol (Ketofol) on Cerebral Oxygenation in Neurosurgical Patients: A Randomized Double-Blinded Controlled Trial.
Brain relaxation
cerebral oxygenation
hemodynamics
ketofol
Journal
Anesthesia, essays and researches
ISSN: 0259-1162
Titre abrégé: Anesth Essays Res
Pays: India
ID NLM: 101578762
Informations de publication
Date de publication:
Historique:
received:
09
08
2019
revised:
25
09
2019
accepted:
29
09
2019
entrez:
4
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
ppublish
Résumé
The effects of ketofol (a combination of ketamine and propofol) on systemic hemodynamics and requirement of opioids/Propofol have already been studied and published. However, there is paucity in the literature on the effects of ketofol on cerebral oxygenation. This study aims to compare the effects of ketofol (ketamine + propofol [1:5]) with propofol on cerebral oxygenation using jugular venous oxygen saturation (SjVO2), in patients undergoing surgical clipping of intracranial aneurysms. A total of 40 World Federation of Neurosurgeons I and II patients were randomized into ketofol ( Entire SjVO2 values in both groups were within the normal limits. Higher SjVO2 values were observed in ketofol group compared to propofol at 1 and 2 h after starting of the drug and at 6 h after surgery ( Maintenance of anesthesia with ketofol provides better cerebral oxygenation and hemodynamic stability compared to propofol in neurosurgical patients.
Sections du résumé
BACKGROUND
BACKGROUND
The effects of ketofol (a combination of ketamine and propofol) on systemic hemodynamics and requirement of opioids/Propofol have already been studied and published. However, there is paucity in the literature on the effects of ketofol on cerebral oxygenation. This study aims to compare the effects of ketofol (ketamine + propofol [1:5]) with propofol on cerebral oxygenation using jugular venous oxygen saturation (SjVO2), in patients undergoing surgical clipping of intracranial aneurysms.
MATERIALS AND METHODS
METHODS
A total of 40 World Federation of Neurosurgeons I and II patients were randomized into ketofol (
RESULTS
RESULTS
Entire SjVO2 values in both groups were within the normal limits. Higher SjVO2 values were observed in ketofol group compared to propofol at 1 and 2 h after starting of the drug and at 6 h after surgery (
CONCLUSION
CONCLUSIONS
Maintenance of anesthesia with ketofol provides better cerebral oxygenation and hemodynamic stability compared to propofol in neurosurgical patients.
Identifiants
pubmed: 32009709
doi: 10.4103/aer.AER_119_19
pii: AER-13-643
pmc: PMC6937901
doi:
Types de publication
Journal Article
Langues
eng
Pagination
643-648Informations de copyright
Copyright: © 2019 Anesthesia: Essays and Researches.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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