Time To Response In Patients With Advanced Anaplastic Lymphoma Kinase (

Alectinib is a highly selective and potent ALK inhibitor, approved for the treatment of patients with metastatic This exploratory analysis of two Phase II studies of alectinib (NP28673/NP28761) investigated time to systemic response (TTR) and time to central nervous system (CNS) response (TTCR) in patients with previously treated advanced anaplastic lymphoma kinase fusion gene-positive ( For NP28673 and NP28761, respectively: median follow-up was 21.3 months/17.0 months; most responders (72.6%/82.9%) responded by the first disease assessment; median TTR was 8 weeks (95% confidence interval [CI]: 8.00-8.14)/6 weeks (95% CI: 5.86-6.14); median TTCR in responders with measurable baseline CNS disease was 8 weeks (95% CI: 7.86-10.29)/6 weeks (95% CI: 5.71-not evaluable). Similar results were observed regardless of measurable/non-measurable disease. These data suggest that alectinib achieves a rapid response in patients, both systemically and in the CNS.

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© 2019 Gadgeel et al.

Déclaration de conflit d'intérêts

SG has received consultancy fees from Araid, Genentech/Roche, and AstraZeneca and personal fees from Genentech/Roche, Takeda, AstraZeneca, Xcovery, and Boehringer-Ingelheim, during the conduct of the study. ATS has received fees for consulting and advisory boards from Pfizer, Novartis, Chugai, Genentech/Roche, Ariad, Daiichi-Sankyo, and Blueprint Medicines; consultancy fees from Ignyta, Taiho, and Foundation Medicine; and advisory board fees from Loxo, EMD Serono, and Natera. FB has received consulting fees and honorarium from F. Hoffmann-La Roche Ltd.; and consultancy fees from AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Clovis Oncology, Eli Lilly Oncology, Novartis, Merck, MSD, Pierre Fabre, Takeda, and Pfizer. JCHY has received fees for advisory board/speech from Boehringer Ingelheim, AstraZeneca, Roche/Genentech, Chugai, BMS, Ono Pharmaceuticals, and Pfizer; and advisory board fees from Bayer, Eli Lilly, MSD, Merck Serono, Novartis, Celgene, Merrimack, Yuhan Pharmaceuticals, Hansoh Pharmaceuticals, Takeda Pharmaceuticals, Blueprint Medicines, G1 Therapeutics, and Daiichi Sankyo. AMD has received consulting fees and honorarium from Roche; and consulting fees from BMS, Eli Lilly, AstraZeneca, Clovis, MSD, Takeda, and Boehringer Ingelheim. DWK has received non-financial support from F. Hoffmann-La Roche Ltd. for travel to meetings for the study or other purposes, and provision of writing assistance, medicines, equipment, or administrative support; and non-financial support from Novartis Oncology for travel to advisory meetings. FDM has received personal fees from AstraZeneca, MSD, Bristol-Myers Squibb, and Roche. MS is an employee of Genentech and holds Roche shares and Settled Stock Appreciation Rights. SL was an employee of Genentech during the study conduct. RG is an employee of Genentech. VS is an employee of F. Hoffmann-La Roche Ltd. SHIO has received personal fees from Pfizer, Roche, AstraZeneca, Merck, and Takeda/ARIAD, Foundation Medicine Inc., owns stock from and a member of the Scientific Advisory Board of Turning Point Therapeutics Inc., outside the submitted work. The authors report no other conflicts of interest in this work.