The Acute Effects of Amyloid-Beta

Alzheimer’s disease amyloid beta glutamate receptor glutamate transporter hippocampus

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2019
Historique:
received: 29 08 2019
accepted: 17 12 2019
entrez: 4 2 2020
pubmed: 6 2 2020
medline: 6 2 2020
Statut: epublish

Résumé

Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms which drive its progression. Glutamate is the main excitatory neurotransmitter in the brain and plays an essential role in the normal function and excitability of neuronal networks. While previous studies have shown alterations in the function of the glutamatergic system in AD, the underlying etiology of beta amyloid (Aβ

Identifiants

DOI: 10.3389/fnins.2019.01427 PMID: 32009891 PMC: PMC6978747
pubmed: 32009891
doi: 10.3389/fnins.2019.01427
pmc: PMC6978747
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1427

Informations de copyright

Copyright © 2020 Yeung, Palpagama, Tate, Peppercorn, Waldvogel, Faull and Kwakowsky.

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Auteurs

Jason H Y Yeung (JHY)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Thulani H Palpagama (TH)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Warren P Tate (WP)

Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Katie Peppercorn (K)

Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Henry J Waldvogel (HJ)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Richard L M Faull (RLM)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Andrea Kwakowsky (A)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Classifications MeSH