Antidiabetic Drug Metformin Ameliorates Depressive-Like Behavior in Mice with Chronic Restraint Stress via Activation of AMP-Activated Protein Kinase.
AMP-activated protein kinase
Compound C
antidepressant
chronic restraint stress
depression
metformin
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
22
01
2019
accepted:
03
04
2019
entrez:
4
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
Depression is one of the most prevalent neuropsychiatric disorders in modern society. However, traditional drugs, such as monoaminergic agents, have defect showing lag response requiring several weeks to months. Additionally, these drugs have limited efficacy and high resistance rates in patients with depression. Thus, there is an urgent need to develop novel drugs or approaches for the treatment of depression. Here, using biochemical, pharmacological, genetic and behavioral methods, we demonstrate that metformin imparts a fast-acting antidepressant-like effect in naïve mice as well as stressed mice subjected to chronic restraint stress model. Moreover, inhibition of AMP-activated protein kinase (AMPK) activity by compound C or knock down of hippocampal AMPKα occluded the antidepressant-like effect induced by metformin. Our results suggest that metformin may be a viable therapeutic drug for the treatment of stress-induced depression via activation of AMPK.
Identifiants
pubmed: 32010479
doi: 10.14336/AD.2019.0403
pii: ad-11-1-31
pmc: PMC6961762
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31-43Informations de copyright
Copyright: © 2019 Ai et al.
Déclaration de conflit d'intérêts
Declarations of interests The authors declare no conflict of interest
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