In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Jan 2020
01 Jan 2020
Historique:
received:
22
10
2019
revised:
09
12
2019
accepted:
11
12
2019
entrez:
4
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
Cervical cancer incidence and mortality rates remain high in medically underserved areas. In this study, we present a low-cost (<$5,000), portable and user-friendly confocal microendoscope, and we report on its clinical use to image precancerous lesions in the cervix. The confocal microendoscope employs digital apertures on a digital light projector and a CMOS sensor to implement line-scanning confocal imaging. Leveraging its versatile programmability, we describe an automated aperture alignment algorithm to ensure clinical ease-of-use and to facilitate technology dissemination in low-resource settings. Imaging performance is then evaluated in
Identifiants
pubmed: 32010516
doi: 10.1364/BOE.381064
pii: 381064
pmc: PMC6968771
doi:
Types de publication
Journal Article
Langues
eng
Pagination
269-280Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA186132
Pays : United States
Informations de copyright
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
One author (Richards-Kortum R) is named as an inventor on patent applications for high resolution imaging owned by Rice University and The University of Texas. The authors report no other conflicts of interest.
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