Role of Sirtuins in Tumor Angiogenesis.
endothelial cells
histone deacetylases
metabolism
signaling pathways
sirtuins
tumor angiogenesis
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
11
2019
accepted:
16
12
2019
entrez:
4
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
Generally, changes in the metabolic status of cells under conditions like hypoxia and accumulation of lactate can be sensed by various sensing mechanisms, leading to modulation of a number of signal transduction pathways and transcription factors. Several of the proangiogenic cytokines like VEGF, FGF, PDGF, TGF-β, Ang-2, ILs, etc. are secreted by cancer cells, under hypoxic microenvironment. These cytokines bind to their receptors on the endothelial cells and activates a number of signaling pathways including Akt/PIP3, Src, p38/MAPK, Smad2/3, etc., which ultimately results in the proliferation and migration of endothelial cells. Transcription factors that are activated in response to the metabolic status of tumors include HIFs, NF-κb, p53, El-2, and FOXO. Many of these transcription factors has been reported to be regulated by a class of histone deacetylase called sirtuins. Sirtuins are NAD
Identifiants
pubmed: 32010617
doi: 10.3389/fonc.2019.01516
pmc: PMC6978795
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1516Informations de copyright
Copyright © 2020 Edatt, Poyyakkara, Raji, Ramachandran, Shankar and Kumar.
Références
Cancer Res. 2011 Aug 1;71(15):5296-306
pubmed: 21653678
Nature. 2010 Mar 4;464(7285):121-5
pubmed: 20203611
Mol Cell Biol. 1996 Sep;16(9):4604-13
pubmed: 8756616
Anticancer Res. 2009 Dec;29(12):5103-9
pubmed: 20044623
J Biol Chem. 2005 Jun 3;280(22):21313-20
pubmed: 15795229
Cell Metab. 2014 Apr 1;19(4):605-17
pubmed: 24703693
Nitric Oxide. 2005 Mar;12(2):97-104
pubmed: 15740983
Int J Dev Biol. 2009;53(2-3):303-22
pubmed: 19378253
Int J Mol Sci. 2013 Mar 11;14(3):5633-49
pubmed: 23478437
Exp Cell Res. 2018 Jun 15;367(2):232-240
pubmed: 29614311
Cell Metab. 2017 Apr 4;25(4):838-855.e15
pubmed: 28380376
J Cell Sci. 2018 Nov 20;131(22):
pubmed: 30333138
Mol Cell Proteomics. 2011 Dec;10(12):M111.012658
pubmed: 21908771
Mol Med Rep. 2016 Mar;13(3):2187-93
pubmed: 26781771
Nature. 2012 Jul 5;487(7405):114-8
pubmed: 22722849
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7
pubmed: 15220471
Science. 2004 Mar 26;303(5666):2011-5
pubmed: 14976264
Cancer Cell. 2005 Jan;7(1):77-85
pubmed: 15652751
Cell. 2013 Aug 1;154(3):651-63
pubmed: 23911327
J Cell Biochem. 2017 Feb;118(2):252-262
pubmed: 27302189
Mol Cancer Ther. 2013 Apr;12(4):499-508
pubmed: 23339189
J Cell Physiol. 2018 Apr;233(4):3498-3514
pubmed: 28929578
Cancer Cell. 2008 Oct 7;14(4):312-23
pubmed: 18835033
Adv Hematol. 2012;2012:843085
pubmed: 22505939
Science. 2011 Nov 11;334(6057):806-9
pubmed: 22076378
Oxid Med Cell Longev. 2019 May 9;2019:6387357
pubmed: 31210843
EMBO J. 2004 Jun 16;23(12):2369-80
pubmed: 15152190
Oxid Med Cell Longev. 2017;2017:1750306
pubmed: 29234485
Annu Rev Biochem. 2006;75:435-65
pubmed: 16756498
Biochem J. 2003 Mar 15;370(Pt 3):737-49
pubmed: 12429021
J Biol Chem. 2005 Apr 22;280(16):16456-60
pubmed: 15716268
Cell. 2001 Apr 20;105(2):269-79
pubmed: 11336676
PLoS One. 2010 May 05;5(5):e10486
pubmed: 20463968
Free Radic Biol Med. 2016 Jul;96:211-22
pubmed: 27101740
Cytokine. 2015 Dec;76(2):549-552
pubmed: 26174951
Biochem Biophys Res Commun. 2003 Jan 31;301(1):250-7
pubmed: 12535671
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9083-7
pubmed: 22890609
Science. 2009 Aug 28;325(5944):1139-42
pubmed: 19628817
Genes Dev. 2004 Apr 15;18(8):901-11
pubmed: 15107403
Genes Dev. 2007 Apr 15;21(8):920-8
pubmed: 17437997
Biomed Pharmacother. 2018 Jun;102:295-301
pubmed: 29567543
Invest Ophthalmol Vis Sci. 2012 Jun 28;53(7):4315-22
pubmed: 22669716
Toxicol Lett. 2014 May 2;226(3):320-7
pubmed: 24603126
Nat Med. 2009 Feb;15(2):206-10
pubmed: 19151729
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6700-5
pubmed: 23569259
Oncogene. 2011 Jun 30;30(26):2986-96
pubmed: 21358671
PLoS One. 2013 Dec 20;8(12):e83620
pubmed: 24376725
Biofactors. 2010 Sep-Oct;36(5):383-93
pubmed: 20848588
Mol Cell. 2003 Jul;12(1):51-62
pubmed: 12887892
Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E110-6
pubmed: 20424141
EMBO J. 2011 Nov 16;30(22):4554-70
pubmed: 21915097
J Atheroscler Thromb. 2010 May;17(5):431-5
pubmed: 20215708
J Mol Cell Cardiol. 2017 Nov;112:104-113
pubmed: 28935506
Elife. 2014 Nov 04;3:
pubmed: 25369635
Cell. 2009 Jan 9;136(1):62-74
pubmed: 19135889
Cell. 2001 Oct 19;107(2):149-59
pubmed: 11672523
Mol Biol Cell. 2005 Oct;16(10):4623-35
pubmed: 16079181
Int J Physiol Pathophysiol Pharmacol. 2016 Sep 30;8(3):120-127
pubmed: 27785339
Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9
pubmed: 10381378
Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):711-7
pubmed: 18239155
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16013-8
pubmed: 16247014
Science. 2000 Sep 22;289(5487):2126-8
pubmed: 11000115
Elife. 2014 Jun 17;3:e02349
pubmed: 24940000
Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8
pubmed: 10873683
Cell. 2001 Oct 19;107(2):137-48
pubmed: 11672522
Nature. 2000 Feb 17;403(6771):795-800
pubmed: 10693811
Cell. 1998 Oct 30;95(3):365-77
pubmed: 9814707
Am J Pathol. 2002 Feb;160(2):711-9
pubmed: 11839592
J Mol Med (Berl). 2007 Nov;85(11):1175-86
pubmed: 17589818
Biochem Biophys Res Commun. 2010 Aug 6;398(4):735-40
pubmed: 20627091
Oncogene. 2002 Mar 27;21(13):2000-8
pubmed: 11960372
Cancer Cell. 2011 Mar 8;19(3):416-28
pubmed: 21397863
J Mater Chem B. 2015 Aug 14;3(30):6338-6346
pubmed: 32262752
Immunity. 2007 Feb;26(2):227-39
pubmed: 17306568
Biochemistry. 2015 May 19;54(19):3037-3050
pubmed: 25897714
Mol Cell Biol. 2003 May;23(9):3173-85
pubmed: 12697818
Biochem J. 2014 Nov 15;464(1):157-68
pubmed: 25162939
PLoS One. 2010 Oct 21;5(10):e13502
pubmed: 20975832
Front Cell Dev Biol. 2018 Sep 11;6:100
pubmed: 30255018
Cancer Res. 2014 Oct 1;74(19):5507-19
pubmed: 25085245
Nature. 2003 May 8;423(6936):181-5
pubmed: 12736687
Circ Res. 2008 Mar 28;102(6):703-10
pubmed: 18239138
Cancer Res. 2001 Aug 15;61(16):6020-4
pubmed: 11507045
Cell. 2014 Dec 18;159(7):1615-25
pubmed: 25525879
Expert Opin Ther Pat. 2009 Mar;19(3):283-94
pubmed: 19441904
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12715-12720
pubmed: 27791113
Mol Cell Biol. 2016 Sep 26;36(20):2553-67
pubmed: 27457618
Nature. 2011 May 12;473(7346):234-8
pubmed: 21499261
J Biol Chem. 2013 Oct 25;288(43):31350-6
pubmed: 24052263
PLoS One. 2012;7(9):e45331
pubmed: 23028940
Chem Rev. 2015 Mar 25;115(6):2350-75
pubmed: 25804908
J Biol Chem. 2012 Nov 30;287(49):40924-37
pubmed: 23086953
Oncotarget. 2017 Dec 15;8(69):114300-114313
pubmed: 29371988
Oxid Med Cell Longev. 2017;2017:7543973
pubmed: 28546854
Oncol Rep. 2012 Jun;27(6):1726-32
pubmed: 22470132
PLoS One. 2014 Dec 09;9(12):e114388
pubmed: 25489948
Mol Cell. 2003 Feb;11(2):437-44
pubmed: 12620231
Nanomedicine. 2011 Oct;7(5):580-7
pubmed: 21333757
EBioMedicine. 2019 Apr;42:64-75
pubmed: 30904607
Cell. 2012 Dec 7;151(6):1185-99
pubmed: 23217706
Mol Cancer Ther. 2007 Feb;6(2):732-41
pubmed: 17308069
J Cell Mol Med. 2019 Jan;23(1):293-305
pubmed: 30394687
Cell Death Dis. 2018 Dec 18;10(1):9
pubmed: 30584257
J Cell Physiol. 2018 Jan;233(1):238-248
pubmed: 28233301
Oncogene. 2007 Feb 15;26(7):945-57
pubmed: 16909107
Ann Rheum Dis. 2016 Jan;75(1):226-33
pubmed: 25180292
Trends Endocrinol Metab. 2009 Sep;20(7):325-31
pubmed: 19713122
J Clin Invest. 2005 Sep;115(9):2382-92
pubmed: 16100571
Mol Aspects Med. 2013 Dec;34(6):1168-201
pubmed: 23357756
Nature. 2004 Jun 17;429(6993):771-6
pubmed: 15175761
Biochim Biophys Acta. 2010 Aug;1804(8):1591-603
pubmed: 20132909
Appl Microbiol Biotechnol. 2016 Aug;100(15):6643-6652
pubmed: 26883344
Cell. 2005 May 20;121(4):515-527
pubmed: 15907466
J Biol Chem. 2005 Apr 8;280(14):13560-7
pubmed: 15653680
Int J Nanomedicine. 2017 Aug 10;12:5781-5795
pubmed: 28848353
J Biol Chem. 2014 Feb 28;289(9):6091-7
pubmed: 24425865
Cardiovasc Res. 2013 Mar 1;97(3):571-9
pubmed: 23201774
Genes Dev. 2007 Oct 15;21(20):2644-58
pubmed: 17938244
Yakugaku Zasshi. 2011;131(7):1061-72
pubmed: 21720136
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9
pubmed: 12960381
Curr Cancer Drug Targets. 2008 Feb;8(1):19-26
pubmed: 18288940
Cell Metab. 2012 Jun 6;15(6):838-47
pubmed: 22682224
J Biol Chem. 2013 Jul 19;288(29):20768-20775
pubmed: 23750001
Onco Targets Ther. 2015 Apr 30;8:977-84
pubmed: 25995644
Cancer Cell. 2011 Mar 8;19(3):299-300
pubmed: 21397853
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-10229
pubmed: 16788062
Nature. 2013 Apr 4;496(7443):110-3
pubmed: 23552949
Med Sci Monit. 2018 Feb 15;24:951-960
pubmed: 29447140
Antimicrob Agents Chemother. 1996 Jun;40(6):1426-31
pubmed: 8726014
Biochemistry. 2015 Oct 20;54(41):6352-6
pubmed: 26371545
Am J Physiol. 1997 Jul;273(1 Pt 1):C205-13
pubmed: 9252458
J Mol Biol. 2008 Oct 10;382(3):790-801
pubmed: 18680753
Biotechnol J. 2007 Nov;2(11):1360-8
pubmed: 17806102
Nat Commun. 2017 Aug 22;8(1):318
pubmed: 28827661
Mol Cell Biochem. 2016 Dec;423(1-2):197-206
pubmed: 27704463
Am J Pathol. 2010 Jul;177(1):481-92
pubmed: 20472894
Circulation. 2009 Oct 13;120(15):1524-32
pubmed: 19786632
EMBO J. 2001 May 15;20(10):2404-12
pubmed: 11350929
Mol Cancer Res. 2014 Sep;12(9):1244-53
pubmed: 24866770
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14855-60
pubmed: 17785417
Arch Dermatol Res. 2019 Apr;311(3):193-201
pubmed: 30783767
Front Physiol. 2019 Aug 09;10:1006
pubmed: 31447696
Sci Rep. 2016 Jul 29;6:30619
pubmed: 27470938
Glycoconj J. 2014 Oct;31(6-7):427-34
pubmed: 25214198
J Cell Sci. 2007 May 1;120(Pt 9):1607-14
pubmed: 17405818
Nature. 2000 Sep 14;407(6801):249-57
pubmed: 11001068
Science. 2005 Oct 14;310(5746):314-7
pubmed: 16224023
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11
pubmed: 10811920
Front Physiol. 2018 Sep 21;9:1325
pubmed: 30298020
Mol Endocrinol. 2007 Aug;21(8):1745-55
pubmed: 17456799
J Cell Physiol. 2007 Oct;213(1):88-97
pubmed: 17516504
Cell. 2010 Jan 22;140(2):280-93
pubmed: 20141841
Eur Heart J. 2014 Dec 1;35(45):3224-31
pubmed: 25217442
J Biol Chem. 2002 May 24;277(21):18535-44
pubmed: 11893743
Leukemia. 2005 Oct;19(10):1751-9
pubmed: 16121216
Oncogene. 2006 Oct 30;25(51):6817-30
pubmed: 17072330
J Cell Physiol. 2007 May;211(2):477-85
pubmed: 17167776
Circ Res. 2009 Apr 10;104(7):879-86
pubmed: 19265035
Nucleic Acids Res. 2007;35(20):6984-94
pubmed: 17940099
PLoS Biol. 2006 Feb;4(2):e31
pubmed: 16366736
Chem Soc Rev. 2015 Aug 7;44(15):5246-64
pubmed: 25955411
Int J Nanomedicine. 2016 Dec 08;11:6679-6692
pubmed: 27994464