Validation of a new serum granulocyte-macrophage colony-stimulating factor autoantibody testing kit.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
21
09
2019
accepted:
27
11
2019
entrez:
4
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
Very recently, a modest but significant efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy for the treatment of mild to moderate autoimmune pulmonary alveolar proteinosis (aPAP) has been reported. As the ability to measure the level of GM-CSF autoantibody (GMAb) in the serum is required to decide the indication for this therapy, we developed a high-performance GMAb testing kit for clinical use. As the kit succeeded in reducing nonspecific IgG binding to the ELISA plate, the predictive performance shown in the training study to discriminate aPAP patients from healthy subjects was perfect, providing a cut-off value of 1.65 U·mL
Identifiants
pubmed: 32010720
doi: 10.1183/23120541.00259-2019
pii: 00259-2019
pmc: PMC6983497
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: K. Nakata reports grants, personal fees and nonfinancial support from Medical and Biological Laboratories during the conduct of the study. In addition, K. Nakata has a patent “Anti-GM-CSF autoantibodies and reagents” (Japan patent office number 4372904). K. Nakata provided Medical and Biological Laboratories exclusive use of patent. In return, Medical and Biological Laboratories paid royalities to K. Nakata. Conflict of interest: T. Sugi has nothing to disclose. Conflict of interest: K. Kuroda has nothing to disclose. Conflict of interest: K. Yoshizawa has nothing to disclose. Conflict of interest: T. Takada has nothing to disclose. Conflict of interest: R. Tazawa has nothing to disclose. Conflict of interest: T. Ueda has nothing to disclose. Conflict of interest: A. Aoki has nothing to disclose. Conflict of interest: M. Abe has nothing to disclose. Conflict of interest: K. Tatsumi has nothing to disclose. Conflict of interest: R. Eda has nothing to disclose. Conflict of interest: S. Kondoh has nothing to disclose. Conflict of interest: K. Morimoto has nothing to disclose. Conflict of interest: T. Tanaka has nothing to disclose. Conflict of interest: E. Yamaguchi has nothing to disclose. Conflict of interest: A. Takahashi has nothing to disclose. Conflict of interest: M. Oda has nothing to disclose. Conflict of interest: H. Ishii has nothing to disclose. Conflict of interest: S. Izumi has nothing to disclose. Conflict of interest: H. Sugiyama has nothing to disclose. Conflict of interest: A. Nakagawa has nothing to disclose. Conflict of interest: K. Tomii has nothing to disclose. Conflict of interest: M. Suzuki has nothing to disclose. Conflict of interest: S. Konno has nothing to disclose. Conflict of interest: S. Ohkouchi has nothing to disclose. Conflict of interest: T. Hirano has nothing to disclose. Conflict of interest: T. Handa has nothing to disclose. Conflict of interest: T. Hirai has nothing to disclose. Conflict of interest: Y. Inoue has nothing to disclose. Conflict of interest: T. Arai has nothing to disclose. Conflict of interest: K. Asakawa has nothing to disclose. Conflict of interest: T. Sakagami has nothing to disclose. Conflict of interest: T. Tanaka has nothing to disclose. Conflict of interest: A. Mikami has nothing to disclose. Conflict of interest: N. Kitamura has nothing to disclose.
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