Prediction of the Probability of Malignancy in Mucinous Cystic Neoplasm of the Pancreas With Ovarian-Type Stroma: A Nationwide Multicenter Study in Japan.
Adolescent
Adult
Aged
Aged, 80 and over
CA-19-9 Antigen
/ blood
Carcinoembryonic Antigen
/ blood
Female
Humans
Japan
Male
Middle Aged
Neoplasms, Cystic, Mucinous, and Serous
/ blood
Ovary
/ pathology
Pancreatic Neoplasms
/ blood
Probability
Sensitivity and Specificity
Stromal Cells
/ pathology
Young Adult
Journal
Pancreas
ISSN: 1536-4828
Titre abrégé: Pancreas
Pays: United States
ID NLM: 8608542
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
6
2
2020
medline:
26
1
2021
entrez:
4
2
2020
Statut:
ppublish
Résumé
The aim of the study was to develop a formula for predicting the probability of malignancy of mucinous cystic neoplasm (MCN) of the pancreas with ovarian-type stroma. A total of 364 patients were enrolled. A total score was calculated as the sum of the approximate integers of the odds ratios of the predictive factors identified by multivariate analysis. The relationship between the total score and pathological results was assessed. A total of 321 patients had benign MCN and 43 had malignant MCN. Five possible predictive factors were analyzed: 56 years or older, high serum carcinoembryonic antigen level, high carbohydrate antigen 19-9 level, tumor size of 51 mm or greater, and the presence of mural nodules. The total score was significantly higher in patients with malignant MCN (median, 24; range, 0-37) compared with benign MCN (median, 5; range, 0-33; P < 0.001). Receiver operating characteristic curve analysis demonstrated that the area under the curve was 0.86, and the sensitivity and specificity of the total score for discriminating malignant MCNs were 72% and 83%, respectively, using a cut-off value of 22. The current simple formula can predict the malignancy of MCN and may thus contribute to the adequate management of patients with MCN.
Identifiants
pubmed: 32011526
doi: 10.1097/MPA.0000000000001475
pii: 00006676-202002000-00004
doi:
Substances chimiques
CA-19-9 Antigen
0
Carcinoembryonic Antigen
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-186Références
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