Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children.
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
children
relapse
second hematopoietic stem cell transplantation
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
08
2019
accepted:
28
10
2019
pubmed:
6
2
2020
medline:
13
1
2021
entrez:
4
2
2020
Statut:
ppublish
Résumé
Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
745-750Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
Références
Bader, P., Hancock, J., Kreyenberg, H., Goulden, N.J., Niethammer, D., Oakhill, A., Steward, C.G., Handgretinger, R., Beck, J.F. & Klingebiel, T. (2002) Minimal residual disease (MRD) status prior to allogeneic stem cell transplantation is a powerful predictor for post-transplant outcome in children with ALL. Leukemia, 16, 1668-1672.
Bejanyan, N., Weisdorf, D.J., Logan, B.R., Wang, H.L., Devine, S.M., de Lima, M., Bunjes, D.W. & Zhang, M.J. (2015) Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow transplant research study. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 21, 454-459.
Bitan, M., He, W., Zhang, M.J., Abdel-Azim, H., Ayas, M.F., Bielorai, B., Carpenter, P.A., Cairo, M.S., Diaz, M.A., Horan, J.T., Jodele, S., Kitko, C.L., Schultz, K.R., Kletzel, M., Kasow, K.A., Lehmann, L.E., Mehta, P.A., Shah, N., Pulsipher, M.A., Prestidge, T., Seber, A., Shenoy, S., Woolfrey, A.E., Yu, L.C. & Davies, S.M. (2014) Transplantation for children with acute myeloid leukemia: a comparison of outcomes with reduced intensity and myeloablative regimens. Blood, 123, 1615-1620.
Bosi, A., Laszlo, D., Labopin, M., Reffeirs, J., Michallet, M., Gluckman, E., Alessandrino, P.E., Locatelli, F., Vernant, J.P., Sierra, J., Jouet, J.P., Frassoni, F. & Acute Leukemia Working Party of the European Blood and Marrow Transplant Group (2001) Second allogeneic bone marrow transplantation in acute leukemia: results of a survey by the European Cooperative Group for Blood and Marrow Transplantation. Journal of Clinical Oncology, 19, 3675-3684.
Christopeit, M., Kuss, O., Finke, J., Bacher, U., Beelen, D.W., Bornhauser, M., Schwerdtfeger, R., Bethge, W.A., Basara, N., Gramatzki, M., Tischer, J., Kolb, H.J., Uharek, L., Meyer, R.G., Bunjes, D., Scheid, C., Martin, H., Niederwieser, D., Kroger, N., Bertz, H., Schrezenmeier, H. & Schmid, C. (2013) Second allograft for hematologic relapse of acute leukemia after first allogeneic stem-cell transplantation from related and unrelated donors: the role of donor change. Journal of Clinical Oncology, 31, 3259-3271.
Eapen, M., Giralt, S.A., Horowitz, M.M., Klein, J.P., Wagner, J.E., Zhang, M.J., Tallman, M.S., Marks, D.I., Camitta, B.M., Champlin, R.E., Ringden, O., Bredeson, C.N., Martino, R., Gale, R.P., Cairo, M.S., Litzow, M.R. & Delima, M. (2004) Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant. Bone Marrow Transplantation, 34, 721-727.
Grimwade, D., Hills, R.K., Moorman, A.V., Walker, H., Chatters, S., Goldstone, A.H., Wheatley, K., Harrison, C.J., Burnett, A.K. & National Cancer Research Institute Adult Leukaemia Working Group (2010) Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood, 116, 354-365.
Guardiola, P., Kuentz, M., Garban, F., Blaise, D., Reiffers, J., Attal, M., Buzyn, A., Lioure, B., Bordigoni, P., Fegueux, N., Tanguy, M.L., Vernant, J.P., Gluckman, E. & Socie, G. (2000) Second early allogeneic stem cell transplantations for graft failure in acute leukaemia, chronic myeloid leukaemia and aplastic anaemia. French Society of Bone Marrow Transplantation. British Journal of Haematology, 111, 292-302.
Kalbfleisch, J.G. & Sprott, D.A. (1974) Statistical analysis of data bearing on the number of particles required to form a plaque. The Journal of Hygiene, 73, 27-34.
Kaplan, E.L. & Meier, P. (1958) Nonparametric-estimation from incomplete observations. Journal of the American Statistical Association, 53, 457-481.
Kaspers, G.J., Zimmermann, M., Reinhardt, D., Gibson, B.E., Tamminga, R.Y., Aleinikova, O., Armendariz, H., Dworzak, M., Ha, S.Y., Hasle, H., Hovi, L., Maschan, A., Bertrand, Y., Leverger, G.G., Razzouk, B.I., Rizzari, C., Smisek, P., Smith, O., Stark, B. & Creutzig, U. (2013) Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group. Journal of Clinical Oncology, 31, 599-607.
Lund, T.C., Ahn, K.W., Tecca, H.R., Hilgers, M.V., Abdel-Azim, H., Abraham, A., Diaz, M.A., Badawy, S.M., Broglie, L., Brown, V., Dvorak, C.C., Gonzalez-Vicent, M., Hashem, H., Hayashi, R.J., Jacobsohn, D.A., Kent, M.W., Li, C.K., Margossian, S.P., Martin, P.L., Mehta, P., Myers, K., Olsson, R., Page, K., Pulsipher, M.A., Shaw, P.J., Smith, A.R., Triplett, B.M., Verneris, M.R. & Eapen, M. (2019) Outcomes after second hematopoietic cell transplantation in children and young adults with relapsed acute leukemia. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 25, 301-306.
Menon, N.N., Jenkins, L.M., Cui, H., Jenkins, C., Anwer, F., Yeager, A.M. & Katsanis, E. (2016) Factors associated with improved outcomes after second allogeneic hematopoietic cell transplantation for relapsed pediatric leukemia. Annals of Hematology, 95, 637-644.
O'Hare, P., Lucchini, G., Cummins, M., Veys, P., Potter, M., Lawson, S., Vora, A., Wynn, R., Peniket, A., Kirkland, K., Pearce, R., Perry, J. & Amrolia, P.J. (2017) Allogeneic stem cell transplantation for refractory acute myeloid leukemia in pediatric patients: the UK experience. Bone Marrow Transplantation, 52, 825-831.
Orti, G., Sanz, J., Bermudez, A., Caballero, D., Martinez, C., Sierra, J., Cabrera Marin, J.R., Espigado, I., Solano, C., Ferra, C., Garcia-Noblejas, A., Jimenez, S., Sampol, A., Yanez, L., Garcia-Gutierrez, V., Pascual, M.J., Jurado, M., Moraleda, J.M., Valcarcel, D., Sanz, M.A., Carreras, E. & Duarte, R.F. (2016) Outcome of second allogeneic hematopoietic cell transplantation after relapse of myeloid malignancies following allogeneic hematopoietic cell transplantation: a retrospective cohort on behalf of the Grupo Espanol de Trasplante Hematopoyetico. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 22, 584-588.
Pession, A., Masetti, R., Rizzari, C., Putti, M.C., Casale, F., Fagioli, F., Lu Ciani, M., Lo Nigro, L., Menna, G., Micalizzi, C., Santoro, N., Testi, A.M., Zecca, M., Biondi, A., Pigazzi, M., Rutella, S., Rondelli, R., Basso, G., Locatelli, F. & AIEOP Study Group (2013) Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia. Blood, 122, 170-178.
Prentice, R.L., Kalbfleisch, J.D., Peterson Jr., A.V., Flournoy, N., Farewell, V.T. & Breslow, N.E. (1978) The analysis of failure times in the presence of competing risks. Biometrics, 34, 541-554.
Rasche, M., Zimmermann, M., Borschel, L., Bourquin, J.P., Dworzak, M., Klingebiel, T., Lehrnbecher, T., Creutzig, U., Klusmann, J.H. & Reinhardt, D. (2018) Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012. Leukemia, 32, 2167-2177.
Roux, C., Tifratene, K., Socie, G., Galambrun, C., Bertrand, Y., Rialland, F., Jubert, C., Pochon, C., Paillard, C., Sirvent, A., Nelken, B., Vannier, J.P., Freycon, C., Beguin, Y., Raus, N., Yakoub-Agha, I., Mohty, M., Dalle, J.H., Michel, G., Pradier, C., Peffault De Latour, R. & Rohrlich, P.S. (2017) Outcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the societe Francophone de greffe de moelle et de therapie cellulaire (SFGM-TC). Bone Marrow Transplantation, 52, 678-682.
Ruutu, T., de Wreede, L.C., van Biezen, A., Brand, R., Mohty, M., Dreger, P., Duarte, R., Peters, C., Garderet, L., Schonland, S., Gratwohl, A., Niederwieser, D., de Witte, T., Kroger, N. & European Society for Bone Marrow Transplantation (2015) Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT. Bone Marrow Transplantation, 50, 1542-1550.
Yaniv, I., Krauss, A.C., Beohou, E., Dalissier, A., Corbacioglu, S., Zecca, M., Afanasyev, B.V., Berger, M., Diaz, M.A., Kalwak, K., Sedlacek, P., Varotto, S., Peters, C. & Bader, P. (2018) Second hematopoietic stem cell transplantation for post-transplantation relapsed acute leukemia in children: a retrospective EBMT-PDWP study. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 24, 1629-1642.