Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy.
GATA3
PD1
follicular lymphoma
lenalidomide
rituximab
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
09
2019
revised:
13
11
2019
accepted:
14
11
2019
pubmed:
6
2
2020
medline:
13
1
2021
entrez:
4
2
2020
Statut:
ppublish
Résumé
Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microenvironment of a clinically well-characterized prospective cohort (study SAKK35/10, NCT01307605) of 154 treatment-naïve FL patients in need of therapy, who have been treated with rituximab only or a combination of rituximab and the immunomodulatory drug lenalidomide/Revlimid® A high ratio of CD4- to CD8-positive T cells (P = 0·009) and increased amounts of PD1
Banques de données
ClinicalTrials.gov
['NCT01307605']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-717Subventions
Organisme : Celgene
Pays : International
Organisme : Swiss State Secretariat for Education, Research and Innovation
Pays : International
Organisme : Stiftung zur Krebsbekämpfung Zürich
ID : 315/2013
Pays : International
Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
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