Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives.
Journal
Rapid communications in mass spectrometry : RCM
ISSN: 1097-0231
Titre abrégé: Rapid Commun Mass Spectrom
Pays: England
ID NLM: 8802365
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
15
11
2019
revised:
29
01
2020
accepted:
31
01
2020
pubmed:
6
2
2020
medline:
6
2
2020
entrez:
4
2
2020
Statut:
ppublish
Résumé
Eicosanoids are short-lived bio-responsive lipids produced locally from oxidation of polyunsaturated fatty acids (FAs) via a cascade of enzymatic or free radical reactions. Alterations in the composition and concentration of eicosanoids are indicative of inflammation responses and there is strong interest in developing analytical methods for the sensitive and selective detection of these lipids in biological mixtures. Most eicosanoids are hydroxy FAs (HFAs), which present a particular analytical challenge due to the presence of regioisomers arising from differing locations of hydroxylation and unsaturation within their structures. In this study, the recently developed derivatization reagent 1-(3-(aminomethyl)-4-iodophenyl)pyridin-1-ium (4-I-AMPP Representative polyunsaturated HFAs (from the hydroxyeicosatetraenoic acid and hydroxyeicosapentaenoic acid families) were derivatized with 4-I-AMPP PD of these complex HFAs was found to be sensitive to the locations of hydroxyl groups and carbon-carbon double bonds, which are structural properties strongly associated with the biosynthetic origins of these lipid mediators.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e8741Subventions
Organisme : Australian Research Council
ID : DP150101715
Organisme : Australian Research Council
ID : DP190101486
Organisme : Australian Research Council
ID : FT110100249
Organisme : Australian Research Council
ID : LP140100711
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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