Brief O
animal models: porcine
autotransplantation
ischemia-reperfusion injury (IRI)
kidney (allograft) function/dysfunction
kidney transplantation/nephrology
organ perfusion and preservation
organ procurement and allocation
translational research/science
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
24
11
2019
revised:
23
01
2020
accepted:
24
01
2020
pubmed:
6
2
2020
medline:
22
6
2021
entrez:
4
2
2020
Statut:
ppublish
Résumé
With oxygenation proposed as a resuscitative measure during hypothermic models of preservation, the aim of this study was to evaluate the optimal start time of oxygenation during continuous hypothermic machine perfusion (HMP). In this porcine ischemia-reperfusion autotransplant model, the left kidney of a ±40 kg pig was exposed to 30 minutes of warm ischemia prior to 22 hours of HMP and autotransplantation. Kidneys were randomized to receive 2 hours of oxygenation during HMP either at the start (n = 6), or end of the perfusion (n = 5) and outcomes were compared to standard, nonoxygenated HMP (n = 6) and continuous oxygenated HMP (n = 8). The brief initial and continuous oxygenated HMP groups were associated with superior graft recovery compared to either standard, nonoxygenated HMP or kidneys oxygenated at the end of HMP. This correlated with significant metabolic differences in perfusate (eg, lactate, succinate, flavin mononucleotide) and tissues (eg, succinate, adenosine triphosphate, hypoxia-inducible factor-1α, nuclear factor erythroid 2-related factor 2) suggesting superior mitochondrial preservation with initial oxygenation. Brief initial O
Identifiants
pubmed: 32012434
doi: 10.1111/ajt.15800
pii: S1600-6135(22)22509-X
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2030-2043Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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