miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury.
Acute Lung Injury
/ etiology
Airway Remodeling
/ genetics
Alveolar Epithelial Cells
/ metabolism
Animals
Chromatography, Liquid
Cytokines
/ genetics
Disease Models, Animal
Disease Susceptibility
Gene Expression Profiling
Male
Mass Spectrometry
Mice
Mice, Knockout
MicroRNAs
/ genetics
Pulmonary Alveoli
/ metabolism
RAW 264.7 Cells
Respiratory Function Tests
Signal Transduction
acute lung injury
alveolar micromechanics
inflammatory signaling
microRNA-21
structural remodeling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jan 2020
27 Jan 2020
Historique:
received:
13
12
2019
revised:
17
01
2020
accepted:
24
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
4
11
2020
Statut:
epublish
Résumé
Acute lung injury (ALI) is characterized by enhanced permeability of the air-blood barrier, pulmonary edema, and hypoxemia. MicroRNA-21 (miR-21) was shown to be involved in pulmonary remodeling and the pathology of ALI, and we hypothesized that miR-21 knock-out (KO) reduces injury and remodeling in ALI. ALI was induced in miR-21 KO and C57BL/6N (wildtype, WT) mice by an intranasal administration of 75 µg lipopolysaccharide (LPS) in saline (
Identifiants
pubmed: 32012801
pii: ijms21030822
doi: 10.3390/ijms21030822
pmc: PMC7037600
pii:
doi:
Substances chimiques
Cytokines
0
MIRN21 microRNA, mouse
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Zentrum für Lungenforschung
ID : -
Organisme : Cluster of excellence "From Regenerative Biology to Reconstructive Therapy" (REBIRTH)
ID : -
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