Tight Junction Proteins and the Biology of Hepatobiliary Disease.
Claudin
NISCH syndrome
blood-biliary barrier
cholangiocellular carcinoma
chronic liver disease
hepatocellular carcinoma
occludin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
04
11
2019
revised:
10
01
2020
accepted:
21
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
5
11
2020
Statut:
epublish
Résumé
Tight junctions (TJ) are intercellular adhesion complexes on epithelial cells and composed of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins have been recognized to play a key role in health and disease. In the liver, TJ proteins have several functions: they contribute as gatekeepers for paracellular diffusion between adherent hepatocytes or cholangiocytes to shape the blood-biliary barrier (BBIB) and maintain tissue homeostasis. At non-junctional localizations, TJ proteins are involved in key regulatory cell functions such as differentiation, proliferation, and migration by recruiting signaling proteins in response to extracellular stimuli. Moreover, TJ proteins are hepatocyte entry factors for the hepatitis C virus (HCV)-a major cause of liver disease and cancer worldwide. Perturbation of TJ protein expression has been reported in chronic HCV infection, cholestatic liver diseases as well as hepatobiliary carcinoma. Here we review the physiological function of TJ proteins in the liver and their implications in hepatobiliary diseases.
Identifiants
pubmed: 32012812
pii: ijms21030825
doi: 10.3390/ijms21030825
pmc: PMC7038100
pii:
doi:
Substances chimiques
Tight Junction Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ARC, Paris and Institut Hospital-Universitaire, Strasbourg
ID : TheraHCC, TheraHCC2.0 IHUARC IHU201301187 and IHUARC2019 IHU201901299
Organisme : European Research Council
ID : 755460
Pays : International
Organisme : European Research Council
ID : 862551
Pays : International
Organisme : Inserm Plan Cancer
ID : Plan Cancer 2014-2019
Organisme : LABEX
ID : ANR-10-LABX-0028_HEPSYS
Organisme : European Research Council
ID : 671231
Pays : International
Organisme : Agence nationale de recherche sur le sida et les hépatites virales (ANRS)
ID : ECTZ35076
Organisme : European Union
ID : ERC-AdG-2014-671231-HEPCIR, EU H2020-667273-HEPCAR and ERC-PoC-2016-PRELICAN
Organisme : Deutsche Forschungsgemeinschaft
ID : RO 5983/1-1
Déclaration de conflit d'intérêts
Inserm, the University of Strasbourg, the Strasbourg University Hospitals and the IHU have filed patent applications and patents on Claudin-1 specific monoclonal antibodies for prevention and treatment of HCV infection and hepatocellular carcinoma which have been licensed to Alentis Therapeutics, Basel, Switzerland.
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