The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein.
allergen
dander
evolution
primate
venom
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
28 01 2020
28 01 2020
Historique:
received:
16
12
2019
revised:
22
01
2020
accepted:
23
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals.
Identifiants
pubmed: 32012831
pii: toxins12020086
doi: 10.3390/toxins12020086
pmc: PMC7076782
pii:
doi:
Substances chimiques
Allergens
0
Glycoproteins
0
Toxins, Biological
0
Fel d 1 protein, Felis domesticus
G408EE88II
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Australian Research Council
ID : DP190100304
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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