Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer.
adavosertib
head and neck cancer
mitotic catastrophe
prexasertib
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
03
12
2019
revised:
20
01
2020
accepted:
23
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
Head and neck squamous cell carcinomas (HNSCC) affect more than 800,000 people annually worldwide, causing over 15,000 deaths in the US. Among HNSCC cancers, human papillomavirus (HPV)-negative HNSCC has the worst outcome, motivating efforts to improve therapy for this disease. The most common mutational events in HPV-negative HNSCC are inactivation of the tumor suppressors
Identifiants
pubmed: 32012873
pii: cancers12020306
doi: 10.3390/cancers12020306
pmc: PMC7072436
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : R50 CA211479
Pays : United States
Organisme : NIH HHS
ID : R01 DK108195
Pays : United States
Organisme : NIH HHS
ID : R21 CA181287
Pays : United States
Organisme : NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211479
Pays : United States
Déclaration de conflit d'intérêts
Barbara Burtness reports consulting fees from Astra-Zeneca. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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