Antibacterial Peptide Nucleic Acids-Facts and Perspectives.
PNA transporters
RNA
antibacterials
bacterial resistance
conjugates
oligonucleotides
peptide nucleic acid (PNA)
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
28
12
2019
revised:
20
01
2020
accepted:
22
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or screening compound libraries, but these strategies have not been successful in recent decades. An alternative approach could be to use gene-specific oligonucleotides, such as peptide nucleic acid (PNA) oligomers, that can specifically target any single pathogen. This approach broadens the range of potential targets to any gene with a known sequence in any bacterium, and could significantly reduce the time required to discover new antimicrobials or their redesign, if resistance arises. We review the potential of PNA as an antibacterial molecule. First, we describe the physicochemical properties of PNA and modifications of the PNA backbone and nucleobases. Second, we review the carriers used to transport PNA to bacterial cells. Furthermore, we discuss the PNA targets in antibacterial studies focusing on antisense PNA targeting bacterial mRNA and rRNA.
Identifiants
pubmed: 32012929
pii: molecules25030559
doi: 10.3390/molecules25030559
pmc: PMC7038079
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Nucleic Acids
0
Peptide Nucleic Acids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Centre, Poland
ID : UMO-2016/23/B/NZ1/03198 and 2017/25/N/NZ1/01578
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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