Brain-Derived Neurotrophic Factor and Diabetes.
brain-derived neurotrophic factor (BDNF)
diabetes mellitus
insulin resistance
neuroprotection
neurotrophins
physical activity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
26
12
2019
revised:
21
01
2020
accepted:
27
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
5
11
2020
Statut:
epublish
Résumé
Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect neuronal tissue and improve the function of the central nervous system, and among them is brain-derived neurotrophic factor (BDNF). The level and function of BDNF in diabetes seems to be disturbed by and connected with the presence of insulin resistance. On the other hand, there is evidence for the highly beneficial impact of physical activity on brain function and BDNF level. However, it is not clear if this protective phenomenon works in the presence of diabetes. In this review, we summarize the current available research on this topic and find that the results of published studies are ambiguous.
Identifiants
pubmed: 32012942
pii: ijms21030841
doi: 10.3390/ijms21030841
pmc: PMC7037992
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Nerve Growth Factors
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Poznan University of Medical Sciences
ID : Grant for Young Scientists
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