The miRNAs Role in Melanoma and in Its Resistance to Therapy.
drug resistance
melanoma
metastasis
miRNAs
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jan 2020
29 Jan 2020
Historique:
received:
13
12
2019
revised:
20
01
2020
accepted:
26
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Melanoma is the less common but the most malignant skin cancer. Since the survival rate of melanoma metastasis is about 10-15%, many different studies have been carried out in order to find a more effective treatment. Although the development of target-based therapies and immunotherapeutic strategies has improved chances for patient survival, melanoma treatment still remains a big challenge for oncologists. Here, we collect recent data about the emerging role of melanoma-associated microRNAs (miRNAs) currently available treatments, and their involvement in drug resistance. We also reviewed miRNAs as prognostic factors, because of their chemical stability and resistance to RNase activity, in melanoma progression. Moreover, despite miRNAs being considered small conserved regulators with the limitation of target specificity, we outline the dual role of melanoma-associated miRNAs, as oncogenic and/or tumor suppressive factors, compared to other tumors.
Identifiants
pubmed: 32013263
pii: ijms21030878
doi: 10.3390/ijms21030878
pmc: PMC7037367
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
MITF protein, human
0
MicroRNAs
0
Microphthalmia-Associated Transcription Factor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Campania
ID : PO FESR 2014-2020
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Oncotarget. 2017 Mar 28;8(13):22262-22278
pubmed: 28118616
Pathologe. 2012 Nov;33 Suppl 2:291-5
pubmed: 22968732
Sci Transl Med. 2018 Dec 12;10(471):
pubmed: 30541787
Pigment Cell Melanoma Res. 2008 Feb;21(1):39-55
pubmed: 18353142
Eur J Cancer. 2005 Jan;41(1):45-60
pubmed: 15617990
Oncogene. 2003 May 19;22(20):3053-62
pubmed: 12789280
Eur J Cancer. 2007 Mar;43(5):935-46
pubmed: 17320377
Oncol Rep. 2017 Nov;38(5):2741-2751
pubmed: 29048639
Clin Cancer Res. 2006 May 1;12(9):2869-78
pubmed: 16675583
Mol Med Rep. 2018 Feb;17(2):3372-3379
pubmed: 29257296
Cancer Res. 2012 Sep 15;72(18):4629-41
pubmed: 22962263
Elife. 2014 Feb 18;3:e01460
pubmed: 24550252
J Exp Clin Cancer Res. 2019 Jun 21;38(1):272
pubmed: 31227006
J Pathol. 2012 Jan;226(1):61-72
pubmed: 22131135
Exp Ther Med. 2018 Dec;16(6):4759-4764
pubmed: 30542430
J Transl Med. 2013 Sep 18;11:218
pubmed: 24047116
Cell. 2006 Mar 24;124(6):1169-81
pubmed: 16564011
Biomolecules. 2018 Apr 26;8(2):
pubmed: 29701682
J Dtsch Dermatol Ges. 2016 Feb;14(2):158-64
pubmed: 26819111
Cancer Res. 2019 Jan 1;79(1):183-195
pubmed: 30425059
Cell Death Dis. 2015 Jan 22;6:e1618
pubmed: 25611392
RNA Biol. 2014;11(6):732-41
pubmed: 24824743
Int J Mol Sci. 2016 Oct 27;17(11):
pubmed: 27801786
Exp Ther Med. 2019 Aug;18(2):997-1004
pubmed: 31316597
PLoS One. 2015 Apr 08;10(4):e0122517
pubmed: 25853464
World J Gastroenterol. 2015 Aug 21;21(31):9337-47
pubmed: 26309359
J Invest Dermatol. 2016 Jun;136(6):1229-1237
pubmed: 26968260
Nat Rev Cancer. 2003 Jun;3(6):411-21
pubmed: 12778131
Sci Rep. 2017 Sep 7;7(1):10909
pubmed: 28883623
Cancer Biol Med. 2018 May;15(2):103-115
pubmed: 29951335
J Biol Chem. 2011 Nov 11;286(45):39172-8
pubmed: 21940630
EBioMedicine. 2019 Oct;48:178-190
pubmed: 31594749
Oncol Rep. 2016 Oct;36(4):2412-20
pubmed: 27573550
J Biol Chem. 2015 Jan 2;290(1):384-95
pubmed: 25414259
Clin Cancer Res. 2009 May 1;15(9):2988-94
pubmed: 19336521
Med Oncol. 2004;21(2):179-85
pubmed: 15299190
Ann Surg Oncol. 2007 Oct;14(10):2854-60
pubmed: 17593331
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Oncogene. 2013 Jun 13;32(24):2984-91
pubmed: 22797068
Oncoimmunology. 2015 Aug 17;5(7):e1052212
pubmed: 27622011
Carcinogenesis. 2015 Sep;36(9):937-45
pubmed: 26071398
J Natl Cancer Inst. 2013 Mar 20;105(6):433-42
pubmed: 23365201
PLoS One. 2016 Jul 29;11(7):e0160221
pubmed: 27472273
PLoS One. 2016 Nov 15;11(11):e0165102
pubmed: 27846237
Cell Rep. 2019 Sep 3;28(10):2728-2738.e7
pubmed: 31484081
J Biol Chem. 2011 May 13;286(19):16606-14
pubmed: 21454583
J Invest Dermatol. 2017 Sep;137(9):1955-1964
pubmed: 28526299
Oncotarget. 2017 Jul 5;8(46):81062-81074
pubmed: 29113367
Expert Opin Biol Ther. 2009 Jun;9(6):703-711
pubmed: 19426115
BMC Cancer. 2019 Jul 5;19(1):665
pubmed: 31277584
N Engl J Med. 1999 Apr 29;340(17):1341-8
pubmed: 10219070
Mol Carcinog. 2016 Aug;55(8):1229-42
pubmed: 26527515
Melanoma Res. 2016 Feb;26(1):21-8
pubmed: 26731559
Nat Med. 2019 Jun;25(6):936-940
pubmed: 31171879
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3207-12
pubmed: 19202062
Cell. 2015 Jan 15;160(1-2):48-61
pubmed: 25594174
Biomedicines. 2014 Aug 04;2(3):211-228
pubmed: 28548068
Oncotarget. 2015 May 20;6(14):12110-27
pubmed: 25883223
Sci Signal. 2019 Jul 23;12(591):
pubmed: 31337739
Am J Pathol. 2012 Nov;181(5):1823-35
pubmed: 22982443
Biochem Pharmacol. 2015 Feb 15;93(4):461-9
pubmed: 25576685
Adv Biomed Res. 2018 Nov 27;7:143
pubmed: 30596053
Oncogene. 2011 May 19;30(20):2304-6
pubmed: 21278792
Cell Res. 2008 May;18(5):549-57
pubmed: 18379589
J Vet Med Sci. 2012 Jan;74(1):1-8
pubmed: 21836381
Exp Ther Med. 2016 Jun;11(6):2513-2518
pubmed: 27284341
J Pathol. 2019 Apr;247(5):539-551
pubmed: 30511391
Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):313-322
pubmed: 30776401
J Clin Invest. 2018 Dec 3;128(12):5505-5516
pubmed: 30260323
J Clin Oncol. 2012 Jul 10;30(20):2522-9
pubmed: 22614978
Cancer Cell. 2011 Jul 12;20(1):104-18
pubmed: 21741600
Cancer Immun. 2012;12:14
pubmed: 22896759
Sci Rep. 2015 Feb 03;5:8201
pubmed: 25643913
Clin Epigenetics. 2019 Jan 16;11(1):9
pubmed: 30651148
Biochem Biophys Res Commun. 2015 Jan 2;456(1):361-6
pubmed: 25475727
Oncotarget. 2018 Aug 21;9(65):32507-32522
pubmed: 30197759
BMC Cancer. 2010 Jun 07;10:262
pubmed: 20529253
Int J Clin Exp Pathol. 2015 Feb 01;8(2):1175-83
pubmed: 25973003
J Cell Biochem. 2019 Jan 30;:
pubmed: 30701576
EBioMedicine. 2015 May 12;2(7):671-80
pubmed: 26288839
PLoS One. 2010 Jul 14;5(7):e11574
pubmed: 20644734
Cell Res. 2009 Apr;19(4):439-48
pubmed: 19238171
Clin Epigenetics. 2015 Jun 04;7:58
pubmed: 26052356
Cancer Biomark. 2019;26(1):63-68
pubmed: 31322550
Oncotarget. 2017 Feb 28;8(9):15894-15911
pubmed: 28199980
Front Immunol. 2019 Apr 02;10:604
pubmed: 31001249
Oncotarget. 2018 Jan 19;9(17):13244-13253
pubmed: 29568354
Cell Rep. 2017 Nov 14;21(7):1936-1952
pubmed: 29141224
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5005-13
pubmed: 27503895
Oncotarget. 2015 Aug 7;6(22):19006-16
pubmed: 26158900
Oncogene. 2003 May 19;22(20):3063-9
pubmed: 12789281
Int J Mol Sci. 2018 Sep 08;19(9):
pubmed: 30205563
PLoS One. 2016 Jul 22;11(7):e0159601
pubmed: 27447934
Cell. 1993 Dec 3;75(5):843-54
pubmed: 8252621
PLoS One. 2013 Sep 05;8(9):e73473
pubmed: 24039954
Hum Pathol. 1984 Dec;15(12):1147-65
pubmed: 6500548
Cancer Res. 2016 Jun 15;76(12):3562-71
pubmed: 27197185
Pigment Cell Res. 1993 Feb;6(1):13-22
pubmed: 8502621
BMC Cancer. 2018 Apr 11;18(1):404
pubmed: 29642855
Onco Targets Ther. 2018 Oct 17;11:7095-7107
pubmed: 30410366
Pigment Cell Melanoma Res. 2008 Feb;21(1):27-38
pubmed: 18353141
Oncotarget. 2015 Feb 20;6(5):2966-80
pubmed: 25650662
Oncotarget. 2016 Sep 27;7(39):63901-63912
pubmed: 27564100
Cancer J. 2007 Jan-Feb;13(1):70-4
pubmed: 17464249
Cancer Res. 2008 Oct 1;68(19):7788-94
pubmed: 18829533
Cancer Res. 2008 Apr 15;68(8):2745-54
pubmed: 18417445
J Natl Cancer Inst. 2003 May 21;95(10):723-32
pubmed: 12759390
Mol Med Rep. 2018 Aug;18(2):2492-2498
pubmed: 29901141
Oncotarget. 2015 Dec 15;6(40):42761-72
pubmed: 26498360
Pigment Cell Melanoma Res. 2017 May;30(3):328-338
pubmed: 28140520
Mol Med Rep. 2019 Aug;20(2):1797-1807
pubmed: 31257538
EBioMedicine. 2016 Oct;12:34-42
pubmed: 27720213
Gene. 2019 Aug 20;710:39-47
pubmed: 31129246
Nature. 2002 Jun 27;417(6892):949-54
pubmed: 12068308
J Thorac Dis. 2019 Jul;11(7):3015-3029
pubmed: 31463131
J Clin Oncol. 2011 Apr 1;29(10):1239-46
pubmed: 21343559
Cell Death Discov. 2017 Jul 10;3:17028
pubmed: 28698805
Biomed Pharmacother. 2016 Dec;84:166-176
pubmed: 27657824
J Invest Dermatol. 2014 Feb;134(2):441-451
pubmed: 23934065
N Engl J Med. 2015 May 21;372(21):2006-17
pubmed: 25891304
Cancer Res. 2012 Jan 15;72(2):460-71
pubmed: 22102694
FEBS Lett. 2013 May 2;587(9):1434-9
pubmed: 23523916
Front Oncol. 2015 Jan 23;4:383
pubmed: 25667918
PLoS One. 2015 Jan 14;10(1):e0115919
pubmed: 25587717
EMBO J. 2011 May 18;30(10):1990-2007
pubmed: 21468029
Cancer Res. 2005 Oct 15;65(20):9328-37
pubmed: 16230395
Radiol Oncol. 2010 Mar;44(1):1-12
pubmed: 22933884
Biomed Pharmacother. 2019 Feb;110:850-856
pubmed: 30557834
J Immunol. 2004 Jul 15;173(2):1444-53
pubmed: 15240741
Pigment Cell Melanoma Res. 2011 Jun;24(3):411-21
pubmed: 21310010
Med Sci (Paris). 2018 Oct;34 Focus issue F1:59-65
pubmed: 30403177
Oncotarget. 2018 Oct 23;9(83):35374-35375
pubmed: 30459929
Pigment Cell Melanoma Res. 2015 Jul;28(4):431-41
pubmed: 25903073
Tumour Biol. 2014 Aug;35(8):8007-15
pubmed: 24839010
Cancer Immunol Immunother. 2016 Nov;65(11):1395-1400
pubmed: 27604993
Cancer Res. 2013 Sep 1;73(17):5402-15
pubmed: 23856247
Oncology (Williston Park). 2009 May;23(6):488-96
pubmed: 19544689
Oncotarget. 2013 Sep;4(9):1399-415
pubmed: 24009080
Oncoimmunology. 2016 Oct 14;5(12):e1238557
pubmed: 28123875
Mol Cancer Res. 2016 Jun;14(6):548-62
pubmed: 27311960
Nat Rev Genet. 2006 Jan;7(1):21-33
pubmed: 16369569
Genes Dev. 2006 Dec 15;20(24):3426-39
pubmed: 17182868
N Engl J Med. 2006 Jul 6;355(1):51-65
pubmed: 16822996
Oncologist. 2010;15(7):765-71
pubmed: 20538743
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1814-9
pubmed: 19188590
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
Cancer Res. 2009 Mar 15;69(6):2287-95
pubmed: 19244118
Biol Open. 2019 Aug 1;8(8):
pubmed: 31371307
Pigment Cell Melanoma Res. 2011 Jun;24(3):538-50
pubmed: 21466664
Oncol Rep. 2018 Dec;40(6):3171-3188
pubmed: 30542718
Oncotarget. 2016 Aug 16;7(33):53735-53750
pubmed: 27447564
Nat Med. 2018 Nov;24(11):1649-1654
pubmed: 30297909
Nat Med. 2002 Aug;8(8):793-800
pubmed: 12091876
Oncol Lett. 2018 May;15(5):6895-6902
pubmed: 29731864
Eur J Cancer Prev. 2017 Nov;26(6):532-541
pubmed: 28125434
Curr Oncol Rep. 2018 Sep 14;20(11):86
pubmed: 30218391
J Natl Cancer Inst. 2017 Oct 1;109(10):
pubmed: 28383653
J Cell Biochem. 2019 Aug;120(8):12412-12421
pubmed: 30825222
Cancer Res. 2008 Mar 1;68(5):1362-8
pubmed: 18316599
N Engl J Med. 2015 Jul 2;373(1):23-34
pubmed: 26027431
CA Cancer J Clin. 2017 Nov;67(6):472-492
pubmed: 29028110
PLoS One. 2017 May 17;12(5):e0177830
pubmed: 28545079
Cancer Res. 2018 Jan 1;78(1):216-229
pubmed: 29093007
Pigment Cell Melanoma Res. 2008 Dec;21(6):665-76
pubmed: 19067971
PLoS One. 2008;3(12):e4029
pubmed: 19107213
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2451-2458
pubmed: 29969627
Clin Lung Cancer. 2009 Jan;10(1):42-6
pubmed: 19289371
Ann Oncol. 2010 Oct;21 Suppl 7:vii339-44
pubmed: 20943639
Cancer Res. 2008 Dec 15;68(24):10128-36
pubmed: 19074879
J Immunol. 2012 Jun 1;188(11):5500-10
pubmed: 22544933
Cell. 2012 Nov 21;151(5):1068-82
pubmed: 23142051
Oncoscience. 2018 Aug 22;5(7-8):248-251
pubmed: 30234146
Mol Oncol. 2014 Jun;8(4):819-29
pubmed: 24656978
Oncotarget. 2016 Aug 16;7(33):53558-53570
pubmed: 27448964
J Dermatol Sci. 2011 Mar;61(3):187-93
pubmed: 21273047
Cancer Lett. 2013 Dec 1;341(2):240-7
pubmed: 23962556
Adv Drug Deliv Rev. 2015 Jan;81:128-41
pubmed: 24859533
Biochem Biophys Res Commun. 2019 Jul 12;515(1):85-91
pubmed: 31128917
Int J Clin Exp Pathol. 2015 May 01;8(5):4913-22
pubmed: 26191184
J Cell Physiol. 2019 Nov;234(11):20193-20205
pubmed: 31016725
Oncol Rep. 2017 Aug;38(2):1276-1286
pubmed: 28656250
Tumour Biol. 2014 Sep;35(9):8359-68
pubmed: 24729125
N Engl J Med. 2005 Nov 17;353(20):2135-47
pubmed: 16291983
Mol Cancer Ther. 2014 Jul;13(7):1918-28
pubmed: 24755198
Br J Cancer. 2016 May 10;114(10):1135-44
pubmed: 27070713
Oncogene. 2003 May 19;22(20):3042-52
pubmed: 12789279
J Surg Res. 2007 Jul;141(1):72-7
pubmed: 17574040
Pigment Cell Melanoma Res. 2011 Jun;24(3):525-37
pubmed: 21435193
Int J Oncol. 2012 Dec;41(6):1897-912
pubmed: 23026890
Genet Mol Res. 2014 Jan 22;13(2):2840-8
pubmed: 24535907
EMBO Rep. 2014 Dec;15(12):1315-29
pubmed: 25341426
Curr Oncol Rep. 2008 Sep;10(5):439-46
pubmed: 18706274
Oncogene. 2008 Nov 6;27(52):6698-706
pubmed: 18679415
J Am Acad Dermatol. 2003 May;48(5):707-13
pubmed: 12734499
J Invest Dermatol. 2020 Jan;140(1):164-173.e7
pubmed: 31580842
Drugs. 2018 Apr;78(5):549-566
pubmed: 29488071
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
Biochem Biophys Res Commun. 2016 May 27;474(2):315-320
pubmed: 27107696
BMC Cancer. 2019 Jul 27;19(1):738
pubmed: 31351450
Br J Cancer. 2012 Jan 31;106(3):553-61
pubmed: 22223089
Clin Transl Med. 2018 Oct 16;7(1):33
pubmed: 30327965
J Invest Dermatol. 2018 Apr;138(4):882-892
pubmed: 29104160
Clin Chem. 2009 Apr;55(4):623-31
pubmed: 19246618
Exp Mol Pathol. 2017 Oct;103(2):172-177
pubmed: 28822769
Nat Genet. 1994 Sep;8(1):15-21
pubmed: 7987387
Nature. 2007 Feb 22;445(7130):851-7
pubmed: 17314971
Methods Mol Biol. 2014;1102:641-53
pubmed: 24259003
Am J Pathol. 2010 May;176(5):2520-9
pubmed: 20304954
Lancet Oncol. 2018 Nov;19(11):1480-1492
pubmed: 30361170
Oncotarget. 2014 Oct 15;5(19):9444-59
pubmed: 25275294
Oncotarget. 2016 Jan 26;7(4):4428-41
pubmed: 26684239
Cell Death Differ. 2019 Jul;26(7):1267-1282
pubmed: 30254376
Carcinogenesis. 2012 Oct;33(10):1823-32
pubmed: 22693259
Nat Rev Cancer. 2006 Nov;6(11):857-66
pubmed: 17060945
Curr Oncol Rep. 2012 Oct;14(5):449-57
pubmed: 22723080
Vet Comp Oncol. 2016 Dec;14(4):384-394
pubmed: 25280339
J Exp Clin Cancer Res. 2019 Jun 13;38(1):255
pubmed: 31196207
Cell Signal. 2013 May;25(5):1212-21
pubmed: 23416459
J Cell Biochem. 2018 Nov 28;:
pubmed: 30485524
ESMO Open. 2019 May 23;4(3):e000491
pubmed: 31231568
Oncol Rep. 2012 Apr;27(4):1200-6
pubmed: 22159356
Eur J Cancer. 2013 Apr;49(6):1297-304
pubmed: 23290787
Curr Mol Med. 2012 Jan;12(1):27-33
pubmed: 22082479
Oncotarget. 2014 Apr 15;5(7):1701-52
pubmed: 24743024
Oncotarget. 2018 Jan 3;9(9):8531-8541
pubmed: 29492214
Cell Cycle. 2012 Feb 15;11(4):785-96
pubmed: 22374676
Cancer Biother Radiopharm. 2018 Jun;33(5):203-211
pubmed: 29916747
J Transl Med. 2016 Feb 24;14:56
pubmed: 26912358
Crit Rev Oncol Hematol. 2019 Jan;133:99-111
pubmed: 30661664
J Natl Cancer Inst. 1996 Dec 4;88(23):1731-7
pubmed: 8944003
Pigment Cell Melanoma Res. 2010 Dec;23(6):853-9
pubmed: 20973935
J Exp Clin Cancer Res. 2018 Sep 25;37(1):238
pubmed: 30253791
Am J Transl Res. 2015 Oct 15;7(10):2053-9
pubmed: 26692949
J Invest Dermatol. 2015 Jul;135(7):1863-1872
pubmed: 25789707
Cell Commun Signal. 2014 Apr 28;12:30
pubmed: 24774301