Influence of Blood-Brain Barrier Integrity on Brain Protein Biomarker Clearance in Severe Traumatic Brain Injury: A Longitudinal Prospective Study.

Adult Biomarkers / blood Blood-Brain Barrier / metabolism Brain Injuries, Traumatic / diagnosis Female Glymphatic System / metabolism Humans Longitudinal Studies Male Middle Aged Phosphopyruvate Hydratase / metabolism Prospective Studies S100 Calcium Binding Protein beta Subunit / metabolism Severity of Illness Index Young Adult
BBB NSE S100B TBI albumin quotient

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
15 06 2020
Historique:
pubmed: 6 2 2020
medline: 8 10 2021
entrez: 5 2 2020
Statut: ppublish

Résumé

Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was to analyze the effect that a disrupted blood-brain barrier (BBB) had on biomarker clearance. Seventeen severe TBI patients admitted to Karolinska University Hospital were prospectively included. Cerebrospinal fluid (CSF) and blood concentrations of S100 calcium binding protein B (S100B) and neuron-specific enolase (NSE) were analyzed every 6-12 h for ∼1 week. Blood and CSF albumin were analyzed every 12-24 h, and BBB integrity was assessed using the CSF:blood albumin quotient (Q

Identifiants

DOI: 10.1089/neu.2019.6741 PMID: 32013731 PMC: PMC7249468
pubmed: 32013731
doi: 10.1089/neu.2019.6741
pmc: PMC7249468
doi:

Substances chimiques

Biomarkers 0
S100 Calcium Binding Protein beta Subunit 0
S100B protein, human 0
Phosphopyruvate Hydratase EC 4.2.1.11

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1381-1391

Subventions

Organisme : NINDS NIH HHS
ID : R03 NS114335
Pays : United States
Organisme : CIHR
ID : 432061
Pays : Canada

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Auteurs

Caroline Lindblad (C)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

David W Nelson (DW)

Department of Section for Perioperative Medicine and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Frederick A Zeiler (FA)

Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, and University of Manitoba, Winnipeg, Manitoba, Canada.
Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, Manitoba, Canada.
Centre on Aging, University of Manitoba, Winnipeg, Manitoba, Canada.
Division of Anaesthesia, Department of Medicine, and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Ari Ercole (A)

Division of Anaesthesia, Department of Medicine, and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Per Hamid Ghatan (PH)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Henrik von Horn (H)

Department of Division of Clinical Chemistry, and Karolinska Institutet, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Mårten Risling (M)

Department of Neuroscience, and Karolinska Institutet, Stockholm, Sweden.

Mikael Svensson (M)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Neurosurgery, Karolinska Institutet, Stockholm, Sweden.

Denes V Agoston (DV)

Department of Neuroscience, and Karolinska Institutet, Stockholm, Sweden.
Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.

Bo-Michael Bellander (BM)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Neurosurgery, Karolinska Institutet, Stockholm, Sweden.

Eric Peter Thelin (EP)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Department of Theme Neuro, Karolinska Institutet, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Influence of Blood-Brain Barrier Integrity on...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Influence of Blood-Brain Barrier Integrity on...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Influence of Blood-Brain Barrier Integrity on...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Influence of Blood-Brain Barrier Integrity on...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Système glymphatique › Influence of Blood-Brain Barrier Integrity on...
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questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Enolase › Influence of Blood-Brain Barrier Integrity on...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines S100 › Sous-unité bêta de la protéine liant le calcium S100 › Influence of Blood-Brain Barrier Integrity on...
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