[Pneumocystis jirovecii colonisation in pregnant women and newborns in Lima, Peru].
Colonización por Pneumocystis jirovecii en mujeres gestantes y recién nacidos en Lima, Perú.
Colonización
Colonization
Gestación
Pneumocystis
Pregnancy
Journal
Revista iberoamericana de micologia
ISSN: 2173-9188
Titre abrégé: Rev Iberoam Micol
Pays: Spain
ID NLM: 9425531
Informations de publication
Date de publication:
Historique:
received:
23
01
2019
revised:
11
09
2019
accepted:
08
11
2019
pubmed:
6
2
2020
medline:
18
2
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
Pneumocystisjirovecii primary infection occurs asymptomatically before 6 months of age, suggesting that the infection is acquired very early in life. Furthermore, Pneumocystis pneumonia has been described in newborns, which emphasizes the importance of studying Pneumocystis colonization in mother-infant pairs. To evaluate the prevalence of Pneumocystis colonization among pregnant women and to determine the potential transplacental transmission. A cross-sectional study was carried out on HIV-negative women over 18 years-old, and 37 or more weeks of pregnancy attending Hospital Cayetano Heredia Maternity unit during 2016-2017. Clinical and demographical information was collected on them and their newborns. Oropharyngeal washes, nasal swabs, and placenta samples were collected from women, as well as a nasopharyngeal aspirate and nasal swab from newborns. All respiratory samples were analysed by nested-PCR for the detection of Pneumocystis. Placenta samples from women with a positive PCR result in their respiratory samples were also analysed by nested-PCR. Of the 92 pregnant women included, five of them (5.43%) were colonized by Pneumocystis. Pneumocystis DNA was not found in any of the 87 available newborn samples or in the placentas of the five women who had a positive result by PCR in their upper respiratory samples. It was found that 5.43% of the pregnant women were colonized by Pneumocystis, there was no evidence of any role of this colonization in the transmission to their newborns, since none of them tested positive for Pneumocystis.
Sections du résumé
BACKGROUND
BACKGROUND
Pneumocystisjirovecii primary infection occurs asymptomatically before 6 months of age, suggesting that the infection is acquired very early in life. Furthermore, Pneumocystis pneumonia has been described in newborns, which emphasizes the importance of studying Pneumocystis colonization in mother-infant pairs.
AIMS
OBJECTIVE
To evaluate the prevalence of Pneumocystis colonization among pregnant women and to determine the potential transplacental transmission.
METHODS
METHODS
A cross-sectional study was carried out on HIV-negative women over 18 years-old, and 37 or more weeks of pregnancy attending Hospital Cayetano Heredia Maternity unit during 2016-2017. Clinical and demographical information was collected on them and their newborns. Oropharyngeal washes, nasal swabs, and placenta samples were collected from women, as well as a nasopharyngeal aspirate and nasal swab from newborns. All respiratory samples were analysed by nested-PCR for the detection of Pneumocystis. Placenta samples from women with a positive PCR result in their respiratory samples were also analysed by nested-PCR.
RESULTS
RESULTS
Of the 92 pregnant women included, five of them (5.43%) were colonized by Pneumocystis. Pneumocystis DNA was not found in any of the 87 available newborn samples or in the placentas of the five women who had a positive result by PCR in their upper respiratory samples.
CONCLUSIONS
CONCLUSIONS
It was found that 5.43% of the pregnant women were colonized by Pneumocystis, there was no evidence of any role of this colonization in the transmission to their newborns, since none of them tested positive for Pneumocystis.
Identifiants
pubmed: 32014345
pii: S1130-1406(19)30090-7
doi: 10.1016/j.riam.2019.11.001
pii:
doi:
Types de publication
Journal Article
Langues
spa
Sous-ensembles de citation
IM
Pagination
24-27Informations de copyright
Copyright © 2019 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.