Follistatin expression in the central nervous system of the adult rat.
Axon
Follistatin
Immunohistochemistry
Neuropil
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
07
11
2019
revised:
30
01
2020
accepted:
30
01
2020
pubmed:
6
2
2020
medline:
7
4
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
Follistatin was initially cloned as a monomeric polypeptide that inhibits the release of follicle-stimulating hormone. Although follistatin also plays pivotal roles in skeletal muscle hypertrophy and immunoregulation in the epididymis, little information is available regarding follistatin function in the adult central nervous system (CNS). Hence, we investigated follistatin expression in the adult rat CNS using immunohistochemistry. Follistatin was intensely expressed in most neurons and their axons. Furthermore, oligodendrocytes, ependymal cells, and some astrocytes also expressed follistatin protein. These data indicate that follistatin is widely expressed throughout the adult CNS. The abundant expression of follistatin in the adult brain suggests that this protein plays important roles in the CNS.
Identifiants
pubmed: 32014555
pii: S0891-0618(19)30204-2
doi: 10.1016/j.jchemneu.2020.101753
pii:
doi:
Substances chimiques
Follistatin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101753Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.