A fully implantable device for diffuse insulin delivery at extraperitoneal site for physiological treatment of type 1 diabetes.

Animals Blood Glucose Diabetes Mellitus, Experimental / drug therapy Diabetes Mellitus, Type 1 / drug therapy Injections, Subcutaneous Insulin / therapeutic use Rats Rats, Wistar Swine
Delivery device Extraperitoneal Hepatic first pass Insulin Type 1 diabetes

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 04 2020
Historique:
received: 11 06 2019
revised: 23 01 2020
accepted: 29 01 2020
pubmed: 6 2 2020
medline: 22 6 2021
entrez: 5 2 2020
Statut: ppublish

Résumé

Intraperitoneal insulin delivery has higher benefits than subcutaneous insulin administration but has limitations, including obstruction of the catheter used in delivery devices. To overcome these limitations this study assessed safety and efficacy of an alternative approach involving a new delivery device, named ExOlin®

Identifiants

DOI: 10.1016/j.jconrel.2020.01.055 PMID: 32014565
pubmed: 32014565
pii: S0168-3659(20)30075-4
doi: 10.1016/j.jconrel.2020.01.055
pii:
doi:

Substances chimiques

Blood Glucose 0
Insulin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

431-441

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Jordan Magisson (J)

Defymed S.A.S, Strasbourg, France.

Aladin Sassi (A)

Defymed S.A.S, Strasbourg, France.

Aram Kobalyan (A)

Defymed S.A.S, Strasbourg, France.

Charles-Thibault Burcez (CT)

Defymed S.A.S, Strasbourg, France.

Richard Bouaoun (R)

Defymed S.A.S, Strasbourg, France.

Michel Vix (M)

IRCAD, Strasbourg, France.

Nathalie Jeandidier (N)

Hôpitaux Universitaires de Strasbourg (HUS), Department of Endocrinology, Diabetes and Metabolic Diseases, Strasbourg, France.

Severine Sigrist (S)

Defymed S.A.S, Strasbourg, France. Electronic address: s.sigrist@defymed.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Diabète expérimental › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections sous-cutanées › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › A fully implantable device for diffuse insulin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › A fully implantable device for diffuse insulin...