Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
19
11
2019
revised:
26
12
2019
accepted:
06
01
2020
pubmed:
6
2
2020
medline:
16
11
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
The poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) impels an improved understanding of disease biology to facilitate the development of better therapies. PDAC typically features a remarkably dense stromal reaction, featuring and established by a prominent population of cancer-associated fibroblasts (CAF). Genetically engineered mouse models and increasingly sophisticated cell culture techniques have demonstrated important roles for fibroblasts in PDAC progression and therapy response, but these roles are complex, with strong evidence for both tumor-supportive and tumor-suppressive or homeostatic functions. Here, we review the recent literature that has improved our understanding of heterogeneity in fibroblast fate and function in this disease including the existence of distinct fibroblast populations, and highlight important avenues for future study. SIGNIFICANCE: Although the abundant stromal reaction associated with pancreatic cancer has long been appreciated, the functions of the CAF cells that establish this stromal reaction remain unclear. An improved understanding of the transcriptional and functional heterogeneity of pancreatic CAFs, as well as their tumor-supportive versus tumor-suppressive capacity, may facilitate the development of effective therapies for this disease.
Identifiants
pubmed: 32014869
pii: 2159-8290.CD-19-1353
doi: 10.1158/2159-8290.CD-19-1353
pmc: PMC8261791
mid: NIHMS1718793
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-656Subventions
Organisme : NCI NIH HHS
ID : R01 CA229580
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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