The Association of

Asian People / genetics Female Genetic Predisposition to Disease Humans Male Matrix Metalloproteinase 7 / genetics Middle Aged Polymorphism, Genetic Risk Factors Stomach Neoplasms / enzymology Taiwan
Gastric cancer MMP7 Taiwan genotype polymorphism

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 02 11 2019
revised: 21 12 2019
accepted: 24 12 2019
entrez: 5 2 2020
pubmed: 6 2 2020
medline: 26 2 2020
Statut: ppublish

Résumé

Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time.
MATERIALS AND METHODS METHODS
A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum.
RESULTS RESULTS
The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population.
CONCLUSION CONCLUSIONS
The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.

Identifiants

DOI: 10.21873/anticanres.13999 PMID: 32014910
pubmed: 32014910
pii: 40/2/695
doi: 10.21873/anticanres.13999
doi:

Substances chimiques

MMP7 protein, human EC 3.4.24.23
Matrix Metalloproteinase 7 EC 3.4.24.23

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

695-702

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Chun-Kai Fu (CK)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Yi-Chun Chien (YC)

Department of Medical Imaging and Radiological Sciences, I-Shou University, Jiaosu Village, Kaohsiung, Taiwan, R.O.C.

Hui-Yen Chuang (HY)

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C.

Yun-Chi Wang (YC)

Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Jeng-Jong Hwang (JJ)

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.

Mei-Due Yang (MD)

Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Chien-Chih Yu (CC)

Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Jaw-Chyun Chen (JC)

Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.

Wen-Shin Chang (WS)

Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C. artbau2@gmail.com wenwen816@gmail.com halittlemelon@hotmail.com.

DA-Tian Bau (DT)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. artbau2@gmail.com wenwen816@gmail.com halittlemelon@hotmail.com.
Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

Chia-Wen Tsai (CW)

Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C. artbau2@gmail.com wenwen816@gmail.com halittlemelon@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Asiatiques › The Association of
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Association of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 7 › The Association of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Association of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › The Association of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The Association of
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › The Association of
questionsmedicales.fr › Régions géographiques › Iles › Taïwan › The Association of