Characteristics of Five-year Survivors After Liver Resection for Colorectal Liver Metastases in Modern Chemotherapy.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Biomarkers, Tumor
Chemotherapy, Adjuvant
Colorectal Neoplasms
/ mortality
Combined Modality Therapy
Female
Hepatectomy
/ adverse effects
Humans
Kaplan-Meier Estimate
Liver Neoplasms
/ diagnosis
Male
Middle Aged
Prognosis
Tomography, X-Ray Computed
CRLM
Colorectal liver metastasis
actual 5-year survivor
modern chemotherapy
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
18
12
2019
revised:
10
01
2020
accepted:
14
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
20
2
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate whether modern chemotherapy has changed characteristics of actual five-year survivors after liver resection for colorectal liver metastasis (CRLM). The records of 210 patients, who underwent curative liver resection for CRLM at our institution between January 1990 and May 2014, were reviewed. The patients treated before 2004 when modern chemotherapy was not introduced were compared with the patients treated after 2005. Actual five-year survivor rates were significantly higher after 2005 (33.3% vs. 49.0%, p=0.022). Preoperative characteristics of actual five-year survivors were not different. The median survival time after non-resectable recurrence was significantly longer after 2005 (20.3 vs. 8.7 months, p=0.002). The proportion of 5-year survivors with recurrent site was significantly higher after 2005 (34.0% vs. 10.5%, p=0.019). Actual five-year survivors have increased by modern chemotherapy. However, approximately one-third of them were not cured.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The aim of this study was to evaluate whether modern chemotherapy has changed characteristics of actual five-year survivors after liver resection for colorectal liver metastasis (CRLM).
PATIENTS AND METHODS
METHODS
The records of 210 patients, who underwent curative liver resection for CRLM at our institution between January 1990 and May 2014, were reviewed. The patients treated before 2004 when modern chemotherapy was not introduced were compared with the patients treated after 2005.
RESULTS
RESULTS
Actual five-year survivor rates were significantly higher after 2005 (33.3% vs. 49.0%, p=0.022). Preoperative characteristics of actual five-year survivors were not different. The median survival time after non-resectable recurrence was significantly longer after 2005 (20.3 vs. 8.7 months, p=0.002). The proportion of 5-year survivors with recurrent site was significantly higher after 2005 (34.0% vs. 10.5%, p=0.019).
CONCLUSION
CONCLUSIONS
Actual five-year survivors have increased by modern chemotherapy. However, approximately one-third of them were not cured.
Identifiants
pubmed: 32014961
pii: 40/2/1107
doi: 10.21873/anticanres.14050
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1107-1116Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.