Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase.
DNA polymerase
foscarnet
human cytomegalovirus
hypersusceptibility
molecular modeling
resistance
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
18
09
2019
accepted:
28
01
2020
pubmed:
6
2
2020
medline:
12
1
2021
entrez:
5
2
2020
Statut:
epublish
Résumé
Herein, we phenotypically and enzymatically characterize the theoretical mutation Q579I in helix K and the already described clinical mutation K805Q in helix P of cytomegalovirus DNA polymerase for susceptibility to foscarnet. Q579I and K805Q recombinant viruses were hypersusceptible to foscarnet (respective mean 50% effective concentrations [EC
Identifiants
pubmed: 32015044
pii: AAC.01910-19
doi: 10.1128/AAC.01910-19
pmc: PMC7179328
pii:
doi:
Substances chimiques
Antiviral Agents
0
DNA, Viral
0
Foscarnet
364P9RVW4X
DNA-Directed DNA Polymerase
EC 2.7.7.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : 148361
Pays : Canada
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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