Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy.
antiretrovirals
bariatric surgery
obesity
sleeve gastrectomy
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
11
12
2019
accepted:
28
01
2020
pubmed:
6
2
2020
medline:
23
2
2021
entrez:
5
2
2020
Statut:
epublish
Résumé
Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.
Identifiants
pubmed: 32015045
pii: AAC.02453-19
doi: 10.1128/AAC.02453-19
pmc: PMC7179309
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Dideoxynucleosides
0
Heterocyclic Compounds, 3-Ring
0
Oxazines
0
Piperazines
0
Pyridones
0
Lamivudine
2T8Q726O95
dolutegravir
DKO1W9H7M1
abacavir
WR2TIP26VS
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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