Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
05
06
2019
accepted:
16
01
2020
revised:
01
11
2019
pubmed:
6
2
2020
medline:
28
1
2022
entrez:
5
2
2020
Statut:
ppublish
Résumé
Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n = 35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (p
Identifiants
pubmed: 32015465
doi: 10.1038/s41380-020-0654-3
pii: 10.1038/s41380-020-0654-3
pmc: PMC7396297
mid: NIHMS1550161
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4496-4510Subventions
Organisme : CIHR
ID : MOP-97800
Pays : Canada
Organisme : NIMH NIH HHS
ID : U01 MH087626
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107108
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085953
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS091859
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100917
Pays : United States
Organisme : CIHR
ID : MOP-74631
Pays : Canada
Organisme : NIMH NIH HHS
ID : P50 MH096891
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019112
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH101722
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH101720
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107235
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH101719
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117946
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH064824
Pays : United States
Organisme : CIHR
ID : MOP-79518
Pays : Canada
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH101724
Pays : United States
Organisme : CIHR
ID : MOP-111238
Pays : Canada
Organisme : CIHR
ID : MOP-89066
Pays : Canada
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K01 MH112774
Pays : United States
Organisme : Wellcome Trust
ID : 102428/Z/13/Z
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH101723
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH087636
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD070454
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090260
Pays : United States
Informations de copyright
© 2020. The Author(s), under exclusive licence to Springer Nature Limited.
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