Effects of Individualized Dialysate Sodium Prescription in Hemodialysis - Results from a Prospective Interventional Trial.
Dialysate sodium
hemodialysis
individualized sodium
sodium set point
Journal
Indian journal of nephrology
ISSN: 0971-4065
Titre abrégé: Indian J Nephrol
Pays: India
ID NLM: 8914356
Informations de publication
Date de publication:
Historique:
received:
27
12
2018
revised:
03
03
2019
accepted:
07
05
2019
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
ppublish
Résumé
Individualized dialysate sodium prescription does affect weight gain, blood pressure (BP), and intradialytic complications. A prospective interventional trial (Dialysate Individualised Sodium (DISO) trial) was conducted to study this issue in Indian patients. Forty patients on thrice-weekly maintenance hemodialysis (HD) for at least 6 weeks were enrolled. The study was performed in two different phases. In the first phase, 12 consecutive HD sessions were done with a standard dialysate sodium concentration of 140 mEq/L. In the second phase, 12 consecutive HD sessions were done with dialysate sodium concentration set to individualized value (mean of pre-HD sodium concentration multiplied by Donnan coefficient of 0.95). Differences in pre- and post-HD sodium, interdialytic weight gain (IDWG), pre- and post-HD BP, thirst scores, and intradialytic adverse events during both phases were assessed. The mean age of patients was 45.65 years (24 males, 16 females). The mean serum pre-HD sodium level was 138.7 ± 1.7 meq/L in the standard phase and 138.2 ± 2.6meq/L in the individualized phase ( The use of individualized dialysate sodium level is safe and results in lower IDWG, pre-HD systolic BP, and intradialytic hypertension in patients on HD.
Identifiants
pubmed: 32015592
doi: 10.4103/ijn.IJN_391_18
pii: IJN-30-3
pmc: PMC6977377
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3-7Informations de copyright
Copyright: © 2020 Indian Journal of Nephrology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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