Bumpy and Smoother Pathways of Puberty Hormone Change: A Novel Way to Define Gonadal Hormone Trajectories in Adolescents.
adolescent
estradiol
longitudinal
puberty
testosterone
urine
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Feb 2020
01 Feb 2020
Historique:
received:
05
08
2019
accepted:
26
11
2019
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
6
2
2020
Statut:
epublish
Résumé
The study of gonadal hormone effects on adolescent wellbeing has been limited by logistical challenges. Urine hormone profiling offers new opportunities to understand the health and behavioral implications of puberty hormones. To characterize pubertal change in urinary testosterone and estradiol among male and female adolescents, respectively. Three-year prospective cohort study. Australian regional community. 282 (163 male) normally developing adolescents aged 11.8 ± 1.0 years at baseline. Quarterly urine measurements of testosterone and estradiol (mass spectrometry); annual anthropometric assessment and Tanner stage (TS) self-report. Two-class sigmoidal and quadratic growth mixture models (centered on age at TS3) were identified as best-fit for describing testosterone (male) and estradiol (female) change. Classes 1 (male: 63%; female: 82%) and 2 (male: 37%; female: 18%) were respectively named the "stable" and "unstable" trajectories, characterized by different standard deviation of quarterly hormone change and magnitude of hormone peaks and troughs (all Adolescents showed 2 distinct urinary gonadal hormone trajectories, characterized by stability of change over time, which were not associated with consistent anthropometric differences. Results provide a methodology for studying gonadal hormone impacts on other aspects of biopsychosocial wellbeing. Identification of potential "at-risk" hormone groups would be important for planning supportive interventions.
Identifiants
pubmed: 32016164
doi: 10.1210/jendso/bvz014
pii: bvz014
pmc: PMC6989013
doi:
Types de publication
Journal Article
Langues
eng
Pagination
bvz014Informations de copyright
© Endocrine Society 2019.
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