Microglia and Parkinson's disease: footprints to pathology.
Inflammation
Microglia
Neurotoxicity
Parkinson’s disease
Therapy
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
30
12
2019
accepted:
26
01
2020
pubmed:
6
2
2020
medline:
27
3
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disease associated with motor deficiency and rigidity. The genetic risks of the disease is reported to be between 5 and 10% depending on the background of the population. While PD is not considered an immune-mediated disease, amounting evidence in recent years suggests a major role of inflammation in the progression of PD. Markers of inflammation can be found around the regions of risk and adjacent to the appearance of Lewy bodies within the basal ganglia and the substantia nigra (SN) that are associated with PD pathology. Microglia, an important type of brain cell, has been reported to play a major role in mediating neuroinflammation and in PD disease pathology. This review aims to point out the potential role of microglia in disease progression and suggest that the interaction of microglia with the dopaminergic neurons may also facilitate the specificity of the disease in brain regions affected by PD.
Identifiants
pubmed: 32016606
doi: 10.1007/s00702-020-02154-6
pii: 10.1007/s00702-020-02154-6
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-158Références
PLoS One. 2013;8(1):e55375
pubmed: 23383169
Brain. 2015 Jan;138(Pt 1):8-10
pubmed: 25564490
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5436-45
pubmed: 17875773
Cell Tissue Res. 2017 Sep;369(3):445-454
pubmed: 28466093
J Neuroinflammation. 2016 Jul 01;13(1):175
pubmed: 27411393
J Physiol. 2017 Mar 15;595(6):1929-1945
pubmed: 27104646
Rejuvenation Res. 2011 Aug;14(4):411-24
pubmed: 21793734
Arch Biochem Biophys. 2018 Feb 15;640:47-52
pubmed: 29336940
Neuropathol Appl Neurobiol. 2016 Aug;42(5):423-35
pubmed: 26300398
Neurol Clin. 2007 Aug;25(3):761-81, vii
pubmed: 17659189
Cell. 2008 May 30;133(5):916-27
pubmed: 18510934
J Neurochem. 2017 Dec;143(5):584-594
pubmed: 28921554
Parkinsonism Relat Disord. 2019 Aug;65:224-229
pubmed: 31255536
Exp Neurol. 1996 Dec;142(2):313-22
pubmed: 8934562
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908195
J Neurosci. 2014 Feb 5;34(6):2231-43
pubmed: 24501362
Ann Neurol. 2005 Feb;57(2):168-75
pubmed: 15668962
Neurobiol Dis. 2012 Jan;45(1):329-36
pubmed: 21889983
Mov Disord. 2020 Jan;35(1):20-33
pubmed: 31680318
Front Cell Neurosci. 2018 Dec 18;12:488
pubmed: 30618635
PLoS One. 2019 Nov 22;14(11):e0225723
pubmed: 31756215
Parkinsonism Relat Disord. 2013 Apr;19(4):407-15
pubmed: 23462481
J Parkinsons Dis. 2017;7(s1):S87-S93
pubmed: 28282818
Annu Rev Physiol. 2017 Feb 10;79:619-643
pubmed: 27959620
Parkinsons Dis. 2011;2011:327089
pubmed: 21603177
J Neurosci. 2015 Mar 18;35(11):4552-70
pubmed: 25788673
Neurosci Lett. 2015 Jan 1;584:191-6
pubmed: 25459294
Cell. 2013 Dec 19;155(7):1596-609
pubmed: 24360280
Ageing Res Rev. 2013 Jun;12(3):749-56
pubmed: 23419464
J Neurochem. 2008 Mar;104(6):1504-25
pubmed: 18036154
J Neurosci. 2013 Nov 6;33(45):17587-96
pubmed: 24198349
Neuron. 2005 Feb 17;45(4):489-96
pubmed: 15721235
Mol Med. 2003 May-Aug;9(5-8):125-34
pubmed: 14571320
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Neuroscience. 1990;39(1):151-70
pubmed: 2089275
Nat Neurosci. 2018 Oct;21(10):1359-1369
pubmed: 30258234
J Neurosci. 2009 Apr 1;29(13):3974-80
pubmed: 19339593
PLoS One. 2015 Mar 27;10(3):e0121072
pubmed: 25815475
CNS Neurosci Ther. 2016 May;22(5):351-9
pubmed: 27012974
Dev Cell. 2012 Dec 11;23(6):1189-202
pubmed: 23201120
Brain Struct Funct. 2019 Jan;224(1):363-372
pubmed: 30341742
J Neurochem. 2014 May;129(3):434-47
pubmed: 24355073
Nat Rev Neurosci. 2007 Jan;8(1):57-69
pubmed: 17180163
Am J Pathol. 2011 Aug;179(2):954-63
pubmed: 21801874
J Neurosci Res. 2005 Jan 1-15;79(1-2):172-9
pubmed: 15573406
Annu Rev Immunol. 2014;32:367-402
pubmed: 24471431
Lancet Neurol. 2020 Feb;19(2):170-178
pubmed: 31521533
Cell Mol Neurobiol. 2017 Apr;37(3):461-473
pubmed: 27178562
Acta Neuropathol Commun. 2014 Aug 07;2:90
pubmed: 25099483
J Neurochem. 2020 Jan;152(1):61-71
pubmed: 31520492
Neurology. 2010 Mar 23;74(12):995-1002
pubmed: 20308684
Front Cell Neurosci. 2018 Aug 30;12:282
pubmed: 30214398
Mol Neurodegener. 2019 Aug 16;14(1):34
pubmed: 31419995
Nat Rev Neurol. 2010 Apr;6(4):193-201
pubmed: 20234358
Brain. 2015 Sep;138(Pt 9):2687-700
pubmed: 26137956
Mol Neurodegener. 2019 Jul 22;14(1):29
pubmed: 31331359
Acta Neuropathol. 2003 Dec;106(6):518-26
pubmed: 14513261
Brain Res Bull. 2000 Aug;52(6):525-30
pubmed: 10974492
Neurology. 1988 Aug;38(8):1285-91
pubmed: 3399080
Trends Neurosci. 2007 Oct;30(10):527-35
pubmed: 17904651
Mol Neurodegener. 2019 Apr 5;14(1):16
pubmed: 30953527
Cell Death Dis. 2019 Feb 20;10(3):174
pubmed: 30787269
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61
pubmed: 26124091
J Neurosci. 2002 Mar 1;22(5):1763-71
pubmed: 11880505
J Neuroinflammation. 2019 Apr 11;16(1):80
pubmed: 30975183
Clin Pharmacol Ther. 2019 May;105(5):1106-1120
pubmed: 30661251
Exp Neurol. 2016 Dec;286:83-92
pubmed: 27697481
Neurosci Res. 2011 Apr;69(4):337-42
pubmed: 21255620
J Neurochem. 2008 Jun;105(5):1726-36
pubmed: 18248618
J Neuroinflammation. 2006 Oct 19;3:29
pubmed: 17052351
J Clin Invest. 2015 Mar 2;125(3):978-80
pubmed: 25689259
Biochem Biophys Res Commun. 2016 Oct 28;479(4):881-886
pubmed: 27666480
Neuromodulation. 2016 Jul;19(5):451-8
pubmed: 27018335
Curr Pharm Des. 2005;11(8):999-1016
pubmed: 15777250
Glia. 2018 Nov;66(11):2353-2365
pubmed: 30394585
J Neurosci. 2012 Feb 1;32(5):1602-11
pubmed: 22302802
Front Cell Neurosci. 2018 Aug 06;12:247
pubmed: 30127724
Brain. 2015 Jan;138(Pt 1):203-16
pubmed: 25472798
Neuropathol Appl Neurobiol. 2013 Feb;39(1):3-18
pubmed: 23252647
Science. 2017 Dec 15;358(6369):1440-1443
pubmed: 29242346
FASEB J. 2005 Apr;19(6):533-42
pubmed: 15791003
Epilepsy Curr. 2018 Mar-Apr;18(2):128-130
pubmed: 29670490
Cold Spring Harb Perspect Med. 2012 Sep 01;2(9):a009373
pubmed: 22951445
J Neurosci. 2007 Mar 21;27(12):3328-37
pubmed: 17376993
J Neural Transm (Vienna). 2015 Oct;122(10):1409-19
pubmed: 25894287
Sci Transl Med. 2018 Oct 31;10(465):
pubmed: 30381407
Neurobiol Dis. 2006 Feb;21(2):404-12
pubmed: 16182554