Effect of Placental Growth Factor on Trophoblast-Endothelial Cell Interactions In Vitro.
Angiogenic factor
CXCL12
Placental growth factor
Toll-like receptor
Trophoblast invasion
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
05
2019
accepted:
10
11
2019
pubmed:
6
2
2020
medline:
15
12
2020
entrez:
5
2
2020
Statut:
ppublish
Résumé
Placental growth factor (PlGF) is an important angiogenic factor which has an emerging role in the clinical management of suspected preeclampsia. The role of PlGF in normal placental development is not completely understood and it is uncertain whether PlGF influences trophoblast and endothelial cell interactions central to uterine spiral artery remodelling, especially in variable oxygen conditions. A two-cell model of endovascular invasion was used. Tissue culture plates were coated with Matrigel™, on which fluorescent-labelled uterine microvascular endothelial cells (1 × 10
Identifiants
pubmed: 32016802
doi: 10.1007/s43032-019-00103-7
pii: 10.1007/s43032-019-00103-7
doi:
Substances chimiques
Chemokine CXCL12
0
Vascular Endothelial Growth Factor A
0
Placenta Growth Factor
144589-93-5
FLT1 protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM