Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols.
cancer prevention
humans
tocopherols
tocotrienols
vitamin E
Journal
Molecular carcinogenesis
ISSN: 1098-2744
Titre abrégé: Mol Carcinog
Pays: United States
ID NLM: 8811105
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
11
11
2019
revised:
09
01
2020
accepted:
17
01
2020
pubmed:
6
2
2020
medline:
21
4
2020
entrez:
5
2
2020
Statut:
ppublish
Résumé
α-Tocopherol (α-T) is the major form of vitamin E (VE) in animals and has the highest activity in carrying out the essential antioxidant functions of VE. Because of the involvement of oxidative stress in carcinogenesis, the cancer prevention activity of α-T has been studied extensively. Lower VE intake or nutritional status has been shown to be associated with increased cancer risk, and supplementation of α-T to populations with VE insufficiency has shown beneficial effects in lowering the cancer risk in some intervention studies. However, several large intervention studies with α-T conducted in North America have not demonstrated a cancer prevention effect. More recent studies have centered on the γ- and δ-forms of tocopherols and tocotrienols (T3). In comparison with α-T, these forms have much lower systemic bioavailability but have shown stronger cancer-preventive activities in many studies in animal models and cell lines. γ-T3 and δ-T3 generally have even higher activities than γ-T and δ-T. In this article, we review recent results from human and laboratory studies on the cancer-preventive activities of different forms of tocopherols and tocotrienols, at nutritional and pharmacological levels. We aim to elucidate the possible mechanisms of the preventive actions and discuss the possible application of the available information for human cancer prevention by different VE forms.
Identifiants
pubmed: 32017273
doi: 10.1002/mc.23160
pmc: PMC7255062
mid: NIHMS1551139
doi:
Substances chimiques
Antioxidants
0
Vitamin E
1406-18-4
Tocopherols
R0ZB2556P8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
365-389Subventions
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT007036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA133021
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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