Caspases in Cell Death, Inflammation, and Pyroptosis.
PANoptosis
gasdermin
inflammasome
inflammatory caspase
innate immunity
pyroptosis
Journal
Annual review of immunology
ISSN: 1545-3278
Titre abrégé: Annu Rev Immunol
Pays: United States
ID NLM: 8309206
Informations de publication
Date de publication:
26 04 2020
26 04 2020
Historique:
pubmed:
6
2
2020
medline:
12
8
2021
entrez:
5
2
2020
Statut:
ppublish
Résumé
Caspases are a family of conserved cysteine proteases that play key roles in programmed cell death and inflammation. In multicellular organisms, caspases are activated via macromolecular signaling complexes that bring inactive procaspases together and promote their proximity-induced autoactivation and proteolytic processing. Activation of caspases ultimately results in programmed execution of cell death, and the nature of this cell death is determined by the specific caspases involved. Pioneering new research has unraveled distinct roles and cross talk of caspases in the regulation of programmed cell death, inflammation, and innate immune responses. In-depth understanding of these mechanisms is essential to foster the development of precise therapeutic targets to treat autoinflammatory disorders, infectious diseases, and cancer. This review focuses on mechanisms governing caspase activation and programmed cell death with special emphasis on the recent progress in caspase cross talk and caspase-driven gasdermin D-induced pyroptosis.
Identifiants
pubmed: 32017655
doi: 10.1146/annurev-immunol-073119-095439
pmc: PMC7190443
mid: NIHMS1561859
doi:
Substances chimiques
Biomarkers
0
GSDMA protein, human
0
Neoplasm Proteins
0
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-595Subventions
Organisme : NIAID NIH HHS
ID : R01 AI101935
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124346
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163507
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI101935
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056296
Pays : United States
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