Prenatal and childhood predictors of hair cortisol concentration in mid-childhood and early adolescence.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
06
2019
accepted:
23
01
2020
entrez:
5
2
2020
pubmed:
6
2
2020
medline:
1
5
2020
Statut:
epublish
Résumé
Hair cortisol concentration (HCC) is an increasingly used measure of systemic cortisol concentration. However, determinants of HCC in children and adolescents are unclear because few prospective studies have been conducted to date. We followed 725 children in Project Viva, a pre-birth cohort study of mothers and children, who provided hair samples at mid-childhood (median age: 7.7 years) or early adolescence (median age: 12.9 years). We examined associations of various factors measured from pregnancy to mid-childhood with HCC in mid-childhood and early adolescence, as well as change in HCC between these time points (ΔHCC). There were 426 children with HCC measurements in both mid-childhood and early adolescence, 173 children with measures only in mid-childhood, and 126 with measures only in early adolescence. HCC was lower in mid-childhood (median 1.0pg/mg [interquartile range, IQR: 0.5, 2.4]) than early adolescence (2.2pg/mg [1.1, 4.4]). In multivariable-adjusted regression models, female sex (β = -0.41, 95% CI: -0.67, -0.15) and birth weight-for-gestational age z-score (β = -0.19, 95% CI: -0.33, -0.04) were associated with lower mid-childhood HCC, while prenatal smoking was associated with higher mid-childhood HCC (β = 0.53, 95% CI: 0.04, 1.01). In early adolescence, child age (β = 0.34 per year, 95% CI: 0.21, 0.46) female sex (β = 0.33, 95% CI: 0.10, 0.57), and maternal pre-pregnancy body mass index (β = 0.15 per 5-kg/m2, 95% CI: 0.01, 0.29) were positively associated with HCC. Child anthropometric measures and biomarker concentrations were not associated with HCC. Maternal pre-pregnancy BMI, maternal prenatal smoking, and low birth weight were associated with higher mid-childhood and adolescent HCC. However, few postnatal characteristics were associated with HCC.
Sections du résumé
BACKGROUND
Hair cortisol concentration (HCC) is an increasingly used measure of systemic cortisol concentration. However, determinants of HCC in children and adolescents are unclear because few prospective studies have been conducted to date.
STUDY DESIGN
We followed 725 children in Project Viva, a pre-birth cohort study of mothers and children, who provided hair samples at mid-childhood (median age: 7.7 years) or early adolescence (median age: 12.9 years). We examined associations of various factors measured from pregnancy to mid-childhood with HCC in mid-childhood and early adolescence, as well as change in HCC between these time points (ΔHCC).
RESULTS
There were 426 children with HCC measurements in both mid-childhood and early adolescence, 173 children with measures only in mid-childhood, and 126 with measures only in early adolescence. HCC was lower in mid-childhood (median 1.0pg/mg [interquartile range, IQR: 0.5, 2.4]) than early adolescence (2.2pg/mg [1.1, 4.4]). In multivariable-adjusted regression models, female sex (β = -0.41, 95% CI: -0.67, -0.15) and birth weight-for-gestational age z-score (β = -0.19, 95% CI: -0.33, -0.04) were associated with lower mid-childhood HCC, while prenatal smoking was associated with higher mid-childhood HCC (β = 0.53, 95% CI: 0.04, 1.01). In early adolescence, child age (β = 0.34 per year, 95% CI: 0.21, 0.46) female sex (β = 0.33, 95% CI: 0.10, 0.57), and maternal pre-pregnancy body mass index (β = 0.15 per 5-kg/m2, 95% CI: 0.01, 0.29) were positively associated with HCC. Child anthropometric measures and biomarker concentrations were not associated with HCC.
CONCLUSION
Maternal pre-pregnancy BMI, maternal prenatal smoking, and low birth weight were associated with higher mid-childhood and adolescent HCC. However, few postnatal characteristics were associated with HCC.
Identifiants
pubmed: 32017807
doi: 10.1371/journal.pone.0228769
pii: PONE-D-19-16945
pmc: PMC6999889
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0228769Subventions
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIEHS NIH HHS
ID : K23 ES024803
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030101
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL098048
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023286
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:1-8
pubmed: 23584040
Curr Epidemiol Rep. 2018 Sep;5(3):293-302
pubmed: 30687591
Psychoneuroendocrinology. 2011 Sep;36(8):1193-200
pubmed: 21411229
BMC Pediatr. 2003 Jul 8;3:6
pubmed: 12848901
J Child Obes. 2018;3(2):
pubmed: 29998225
Stress. 2017 Jul;20(4):350-354
pubmed: 28595479
J Clin Endocrinol Metab. 2013 May;98(5):2078-83
pubmed: 23596141
PLoS One. 2016 Apr 20;11(4):e0153800
pubmed: 27097023
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674
Psychoneuroendocrinology. 2016 Apr;66:56-64
pubmed: 26773401
Pediatr Res. 2004 Sep;56(3):311-7
pubmed: 15240866
Stress. 2008 Nov;11(6):483-8
pubmed: 18609301
Psychoneuroendocrinology. 2013 Mar;38(3):331-40
pubmed: 22809790
Acta Paediatr Suppl. 2004 Dec;93(446):26-33
pubmed: 15702667
PLoS One. 2016 Sep 23;11(9):e0163639
pubmed: 27662656
Horm Res Paediatr. 2014;82(2):97-102
pubmed: 25115629
Psychophysiology. 2020 Jan;57(1):e13271
pubmed: 30101980
Obesity (Silver Spring). 2014 Dec;22(12):2586-92
pubmed: 25234485
Forensic Sci Int. 2000 Jan 10;107(1-3):5-12
pubmed: 10689559
J Clin Endocrinol Metab. 2004 Mar;89(3):1227-33
pubmed: 15001615
Psychoneuroendocrinology. 2017 Apr;78:142-150
pubmed: 28199857
Obesity (Silver Spring). 2016 Jan;24(1):184-90
pubmed: 26592489
Pediatrics. 2013 Nov;132(5):e1333-40
pubmed: 24101769
Eur J Endocrinol. 2005 Dec;153(6):811-7
pubmed: 16322386
Int J Obes (Lond). 2006 Apr;30(4):590-4
pubmed: 16570087
Psychoneuroendocrinology. 2004 Feb;29(2):125-40
pubmed: 14604596
Int J Epidemiol. 2015 Feb;44(1):37-48
pubmed: 24639442
Mol Cell Endocrinol. 2016 Nov 5;435:2-6
pubmed: 27392495
Schizophr Res. 2019 Nov;213:65-71
pubmed: 30660575
Psychoneuroendocrinology. 2018 Jan;87:204-214
pubmed: 29112905
Obes Rev. 2018 Jan;19(1):81-97
pubmed: 28849612
J Youth Adolesc. 1980 Jun;9(3):271-80
pubmed: 24318082
Dev Psychopathol. 2012 Nov;24(4):1377-90
pubmed: 23062304
Psychoneuroendocrinology. 2017 Feb;76:1-10
pubmed: 27865992
Psychoneuroendocrinology. 2017 Aug;82:75-82
pubmed: 28511047
Du Bois Rev. 2011 Spring;8(1):95-113
pubmed: 29887911
J Clin Endocrinol Metab. 2012 Oct;97(10):E1836-43
pubmed: 22844063
Pediatr Res. 1995 Apr;37(4 Pt 1):502-6
pubmed: 7596692
BMC Endocr Disord. 2009 Jun 21;9:16
pubmed: 19545400
Res Nurs Health. 2016 Feb;39(1):15-29
pubmed: 26676400
J Youth Adolesc. 1988 Apr;17(2):117-33
pubmed: 24277579
Ann Epidemiol. 2013 Dec;23(12):797-811.e2
pubmed: 24184029
Eur J Endocrinol. 2017 Jun;176(6):695-703
pubmed: 28289104
Dev Psychobiol. 2015 Mar;57(2):212-25
pubmed: 25650169
J Child Psychol Psychiatry. 2017 Sep;58(9):998-1007
pubmed: 28244601
Br J Dermatol. 2001 Aug;145(2):294-7
pubmed: 11531795
Obesity (Silver Spring). 2013 Jan;21(1):E105-17
pubmed: 23505190
Psychoneuroendocrinology. 2018 Mar;89:138-146
pubmed: 29358120
Pediatrics. 2002 Jan;109(1):45-60
pubmed: 11773541
Paediatr Perinat Epidemiol. 2005 Jul;19(4):294-302
pubmed: 15958152