NAD
Animals
Chemical Warfare Agents
/ toxicity
Dietary Supplements
Humans
Mustard Gas
/ toxicity
NAD
/ administration & dosage
Niacinamide
/ administration & dosage
Oxidative Stress
/ drug effects
Poly(ADP-ribose) Polymerases
/ metabolism
Reactive Nitrogen Species
/ metabolism
Sirtuins
/ antagonists & inhibitors
Cytotoxicity
NAD
Nicotinamide adenine dinucleotide
PARP
Sirtuins
Sulfur mustard
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
29
09
2019
revised:
08
01
2020
accepted:
25
01
2020
pubmed:
6
2
2020
medline:
31
3
2020
entrez:
5
2
2020
Statut:
ppublish
Résumé
Sulfur mustard (SM) is a toxicant and chemical warfare agent with strong vesicant properties. The mechanisms behind SM-induced toxicity are not fully understood and no antidote or effective therapy against SM exists. Both, the risk of SM release in asymmetric conflicts or terrorist attacks and the usage of SM-derived nitrogen mustards as cancer chemotherapeutics, render the mechanisms of mustard-induced toxicity a highly relevant research subject. Herein, we review a central role of the abundant cellular molecule nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 32017979
pii: S0378-4274(20)30032-1
doi: 10.1016/j.toxlet.2020.01.024
pii:
doi:
Substances chimiques
Chemical Warfare Agents
0
Reactive Nitrogen Species
0
NAD
0U46U6E8UK
Niacinamide
25X51I8RD4
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
Sirtuins
EC 3.5.1.-
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-103Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.