Modified apple polysaccharide capped gold nanoparticles for oral delivery of insulin.
Administration, Oral
Animals
Biomarkers
Cell Survival
Chromatography, High Pressure Liquid
Drug Carriers
/ chemistry
Drug Delivery Systems
Drug Stability
Gold
/ chemistry
Insulin
/ administration & dosage
Malus
/ chemistry
Metal Nanoparticles
/ chemistry
Particle Size
Polysaccharides
/ chemistry
Rats
Spectrum Analysis
Viscosity
Gold nanoparticles
Insulin
Modified apple polysaccharide
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
received:
07
11
2019
revised:
29
01
2020
accepted:
31
01
2020
pubmed:
6
2
2020
medline:
15
12
2020
entrez:
5
2
2020
Statut:
ppublish
Résumé
The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential -10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced rat model revealed that AuNPs conjugated insulin (AuNPs-INS) in high dose caused 3.36 folds decrease in blood glucose level in 240 min, whereas, orally administered INS failed to decrease the blood glucose level. The 28-day study also revealed better improvement in body weight, lipid profile, urea, creatinine and liver parameters in AuNPs-INS (high dose) for which the observed value was close with respect to intraperitoneally administrated insulin followed by medium dose of AuNPs-INS, low dose of AuNPS-INS, AuNPs alone and modified apple polysaccharide.
Identifiants
pubmed: 32018009
pii: S0141-8130(19)39044-0
doi: 10.1016/j.ijbiomac.2020.01.302
pii:
doi:
Substances chimiques
Biomarkers
0
Drug Carriers
0
Insulin
0
Polysaccharides
0
Gold
7440-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
976-988Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Declared none.