Porcine Liver Anatomy Applied to Biomedicine.
Anatomy
Biomedical research
Domestic pig
Histology
Liver
Journal
The Journal of surgical research
ISSN: 1095-8673
Titre abrégé: J Surg Res
Pays: United States
ID NLM: 0376340
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
04
05
2019
revised:
16
12
2019
accepted:
28
12
2019
pubmed:
6
2
2020
medline:
22
8
2020
entrez:
5
2
2020
Statut:
ppublish
Résumé
Currently, there are at least 70 pure domestic pig breeds, but only certain breeds are used in biomedical research. The domestic pig liver is suitable for preclinical research because its size, physiology, and anatomy are similar to that of the human liver; in addition, there is a high degree of genetic similarity between the two species. For planning experiments and identifying improvements in both invasive and noninvasive methods of liver disease management, the morphological similarities and dissimilarities of the pig liver to its human counterpart must be taken into consideration along with sexual dimorphism and interindividual and interspecific variability. Recent histological evaluations based on stereological methods enable precise quantitative morphological estimates and guarantee their unbiased accuracy. The results thereof are crucial for revealing and assessing histological changes and can contribute to the optimization of study designs. New trends in computed tomography data processing have also been introduced. This review article summarizes the newest trends and findings in the field of porcine liver anatomy and histology as applicable to preclinical research.
Identifiants
pubmed: 32018145
pii: S0022-4804(20)30016-0
doi: 10.1016/j.jss.2019.12.038
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-79Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.