Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.
Animals
Aspergillosis
/ microbiology
Aspergillus fumigatus
/ drug effects
Doxycycline
/ pharmacology
Female
Fungal Proteins
/ genetics
Larva
/ microbiology
Mice
Mice, Inbred BALB C
Moths
/ microbiology
Proof of Concept Study
Spores, Fungal
/ drug effects
Transcription Factors
/ genetics
Virulence
Virulence Factors
Aspergillus fumigatus
RNA sequencing
conidiation
drug targets
inducible gene expression
opportunistic pathogen
virulence
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
04 02 2020
04 02 2020
Historique:
entrez:
6
2
2020
pubmed:
6
2
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Inhalation of conidia of the opportunistic mold
Identifiants
pubmed: 32019801
pii: mBio.03202-19
doi: 10.1128/mBio.03202-19
pmc: PMC7002347
pii:
doi:
Substances chimiques
BrlA protein, Aspergillus fumigatus
0
Fungal Proteins
0
Transcription Factors
0
Virulence Factors
0
Doxycycline
N12000U13O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI130128
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007519
Pays : United States
Informations de copyright
Copyright © 2020 Stewart et al.
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